A Single-center Exploratory Clinical Study to Evaluate the Safety, Tolerability, and Efficacy of a BCMA-targeted Universal LCAR-BCX Cells in Patients With Relapsed/Refractory Multiple Myeloma

PHASE1UnknownINTERVENTIONAL
Enrollment

34

Participants

Timeline

Start Date

October 9, 2020

Primary Completion Date

January 31, 2023

Study Completion Date

October 31, 2024

Conditions
Relapsed/Refractory Multiple Myeloma
Interventions
BIOLOGICAL

LCAR-BCX cells product

In this study, LCAR-BCX CAR+ cells will be evaluated at 5 dose levels including 0.25 × 10\^6 cells/kg, 0.5 × 10\^6 cells/kg, 1.0 × 10\^6 cells/kg, 2.0 × 10\^6 cells/kg, and 4.0 × 10\^6 cells/kg, with 0.25 × 10\^6 cells/kg as the starting dose, to determine RP2D for LCAR-BCX cell therapy

Trial Locations (1)

Unknown

Shanghai Changzheng Hospital, Shanghai

Sponsors
All Listed Sponsors
collaborator

Nanjing Legend Biotech Co.

INDUSTRY

lead

Weijun Fu

OTHER