NCT04595747View on ClinicalTrials.gov

Testing the Anti-cancer Drug, Rogaratinib (BAY 1163877), for Treatment of Advanced Sarcoma With Alteration in Fibroblast Growth Factor Receptor (FGFR 1-4), and in Patients With SDH-deficient Gastrointestinal Stromal Tumor (GIST)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

May 3, 2021

Primary Completion Date

July 1, 2026

Study Completion Date

July 1, 2026

Conditions
Locally Advanced Gastrointestinal Stromal TumorLocally Advanced SarcomaMetastatic Gastrointestinal Stromal TumorMetastatic SarcomaStage III Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8Stage III Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8Stage IV Gastric and Omental Gastrointestinal Stromal Tumor AJCC v8Stage IV Small Intestinal, Esophageal, Colorectal, Mesenteric, and Peritoneal Gastrointestinal Stromal Tumor AJCC v8
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

PROCEDURE

Computed Tomography

Undergo CT scan and PET/CT scan

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT scan

DRUG

Rogaratinib

Given PO

Trial Locations (18)

10065

Memorial Sloan Kettering Cancer Center, New York

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

20892

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

National Institutes of Health Clinical Center, Bethesda

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33324

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

37232

Vanderbilt University/Ingram Cancer Center, Nashville

43210

Ohio State University Comprehensive Cancer Center, Columbus

48109

University of Michigan Comprehensive Cancer Center, Ann Arbor

60611

Northwestern University, Chicago

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

77030

M D Anderson Cancer Center, Houston

80045

UCHealth University of Colorado Hospital, Aurora

91010

City of Hope Comprehensive Cancer Center, Duarte

92618

City of Hope at Irvine Lennar, Irvine

02215

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH