Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF

NAUnknownINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

December 18, 2020

Primary Completion Date

April 30, 2022

Study Completion Date

March 31, 2023

Conditions
Heart Failure With Preserved Ejection Fraction
Interventions
DEVICE

Satera GSN Ablation

The Axon procedure consists of a small needle puncture made in the groin to pass standard sheaths, wires, and access devices into the femoral vein, using standard access methods. The right GSN will be ablated transvenously from the right intercostal veins where it crosses at the 10th and 11th thoracic vertebrae from the intercostal vein intersection with the azygos vein. Placement of the access devices and Axon catheter is confirmed using standard fluoroscopic imaging. Once positioning is confirmed, GSN ablation can commence accordingly .

DEVICE

Sham Control

The sham procedure consists of a small needle puncture made in the groin to pass a standard femoral introducer sheath approximately 10 cm into the femoral vein, using standard access methods. The Axon Catheter and associated access accessories will not be inserted into the patient. The sham procedure duration will be similar to the treatment time for subject receiving the Axon therapy (\~30 minutes).

Trial Locations (17)

10021

RECRUITING

Weill Cornell Medicine, New York

10029

RECRUITING

Icahn School of Medicine at Mount Sinai, New York

10032

RECRUITING

Center for Advanced Cardiac Care, Columbia University Medical Center, New York

23298

NOT_YET_RECRUITING

Virginia Commonwealth University Medical Center, Richmond

27710

RECRUITING

Duke University Medical Center, Durham

29425

RECRUITING

Medical University of South Carolina, Gazes Cardiac Research Institute, Charleston

35211

RECRUITING

Cardiology PC, Birmingham

43210

RECRUITING

Ohio State University Wexner Medical Center, Columbus

48109

RECRUITING

Michigan Medicine, University of Michigan, Ann Arbor

55905

RECRUITING

Mayo Clinic, Rochester

60611

RECRUITING

Bluhm Cardiovascular Institute of Northwestern University, Chicago

60637

NOT_YET_RECRUITING

University of Chicago Medical Center, Chicago

62701

RECRUITING

Prairie Education and Research Cooperative, Springfield

70360

RECRUITING

Cardiovascular Institute of the South, Houma

85016

RECRUITING

Arizona Cardiovascular Research Center, Phoenix

92037

RECRUITING

Scripps Health, La Jolla

94143

RECRUITING

University of California, San Francisco, San Francisco

Sponsors
All Listed Sponsors
lead

Axon Therapies, Inc.

INDUSTRY

NCT04592445 - Endovascular Ablation of the Right Greater Splanchnic Nerve in Subjects Having HFpEF | Biotech Hunter | Biotech Hunter