Does High-dose Vitamin B3 Supplementation Prevent Major Adverse Kidney Events During Septic Shock?

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

310

Participants

Timeline

Start Date

October 1, 2020

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Acute Kidney InjurySeptic ShockNicotinamideMortality
Interventions
DRUG

Nicotinamide treatment

Nicotinamide (500 mg) will be mixed in 50 ml of 0.9% saline and administered intravenously every 12 h for a total of 72 h.

DRUG

placebo treatment

For the placebo group, an identical volume of 0.9% saline will be administered in the same manner.

Trial Locations (1)

80480

CHU Amiens, Amiens

All Listed Sponsors
collaborator

Centre Hospitalier de Dieppe

UNKNOWN

collaborator

Centre Hospitalier d'Abbeville

OTHER

collaborator

Centre Hospitalier de Laon

UNKNOWN

collaborator

University Hospital, Caen

OTHER

collaborator

Centre Hospitalier de Cherbourg

UNKNOWN

collaborator

University Hospital, Rouen

OTHER

collaborator

Centre Hospitalier de Roubaix

OTHER

collaborator

Centre Hospitalier de Bethune

NETWORK

collaborator

Hôpital Saint Philibert, Lomme

UNKNOWN

collaborator

Tourcoing Hospital

OTHER

collaborator

Centre Hospitalier de Valenciennes

NETWORK

collaborator

Centre Hospitalier Arras

OTHER

collaborator

Centre Hospitalier de Lens

OTHER

collaborator

Centre Hospitalier de Calais

UNKNOWN

lead

Centre Hospitalier Universitaire, Amiens

OTHER