Diastolic dYsfunctioN AssessMent in critICally Ill Patients

UnknownOBSERVATIONAL
Enrollment

297

Participants

Timeline

Start Date

June 1, 2021

Primary Completion Date

June 1, 2022

Study Completion Date

June 1, 2022

Conditions
Critical IllnessDiastolic DysfunctionDiastolic Heart FailureWeaning FailureMechanical Ventilation Complication
Interventions
DIAGNOSTIC_TEST

Bedside Echocardiography

"All the intensivists performing the TTE in the involved centers fulfill the criteria of the American Society of Echocardiography and of the European Society of Intensive Care.~Medicine to be considered as experts in critical care echocardiography. Each center performs the TTE evaluation by means of the ultrasound device available in the unit equipped with the tissue Doppler imaging program and a phased array transducer of 2.5 MHz and doppler signals is recorded along with the electrocardiogram.~For the purpose of this study, the following TTE parameters are recorded from the apical 4-chamber view during each set of measurements:"

PROCEDURE

Spontaneuos breathing trial

The Spontaneous Breathing Trial will be performed accordingly to the clinical practice of the involved centers (a total support - including positive end-expiratory pressure plus pressure support equal or lower to 8 cmH20)

DIAGNOSTIC_TEST

Bedside Echocardiography_1

Echocardiography performed within 24h from patient's admission - not optional

DIAGNOSTIC_TEST

Bedside Echocardiography_2

Echocardiography performed within 12h from patient's spontaneous breathing trial - not optional

DIAGNOSTIC_TEST

Bedside Echocardiography_3

Echocardiography performed at 60 +/- 12h from patient's admission - optional

DIAGNOSTIC_TEST

Bedside Echocardiography_4

Echocardiography performed 24h after patient's estubation - optional

Trial Locations (8)

20089

RECRUITING

Humanitas Research Hospital, Rozzano

28100

NOT_YET_RECRUITING

Ospedale Ss. Trinità, Borgomanero

50134

NOT_YET_RECRUITING

Careggi University Hospital, Florence

Unknown

NOT_YET_RECRUITING

"Policlinico-San Marco", Catania

NOT_YET_RECRUITING

Azienda Ospedaliera di Perugia, Perugia

NOT_YET_RECRUITING

Grande Ospedale Metropolitano, Reggio Calabria

NOT_YET_RECRUITING

Policlinico Universitario A. Gemelli, Roma

NOT_YET_RECRUITING

Azienda Sanitaria Universitaria Integrata di Udine, Udine

All Listed Sponsors
lead

Humanitas Clinical and Research Center

OTHER