Flotetuzumab for Relapsed Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Following Allogeneic Hematopoietic Cell Transplantation (Allo-HCT)

PHASE2TerminatedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

May 20, 2021

Primary Completion Date

March 29, 2024

Study Completion Date

July 26, 2024

Conditions
Relapsed Acute Myeloid Leukemia
Interventions
DRUG

Flotetuzumab

Will be provided by MacroGenics Inc.

PROCEDURE

Donor lymphocyte infusion

DLI represents a non-specific form of adoptive cell therapy which involves infusion of a pool of allogeneic immune cells, including CD4+ T cells, CD8+ T cells, regulatory T cells (T Regs), natural killer (NK) cells and professional antigen presenting cells.

Trial Locations (1)

63110

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

MacroGenics

INDUSTRY

collaborator

National Cancer Institute (NCI)

NIH

lead

Washington University School of Medicine

OTHER