Efficacy Comparison of Dostarlimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC)

PHASE2TerminatedINTERVENTIONAL
Enrollment

243

Participants

Timeline

Start Date

November 19, 2020

Primary Completion Date

August 4, 2022

Study Completion Date

September 10, 2024

Conditions
Lung Cancer, Non-Small Cell
Interventions
DRUG

Dostarlimab

Dostarlimab will be administered through a 30 minute infusion at a dose of 500 milligrams (mg) intravenously (IV) every 3 weeks (Q3W) up to a maximum of 35 cycles (each cycle of 21 days).

DRUG

Pembrolizumab

Pembrolizumab will be administered through a 30 minute infusion at a dose of 200 mg Q3W up to a maximum of 35 cycles (each cycle of 21 days).

DRUG

Chemotherapy

"Pemetrexed will be administered at 500 milligram per meter square (mg/m\^2 ) IV through a 10 minute IV infusion Q3W, up to a maximum of 35 cycles (each cycle of 21 days).~Cisplatin will be administered at 75 mg/m\^2 through a 30 minute IV infusion Q3W for 4 cycles (each cycle of 21 days) as per investigator decision.~Carboplatin will also be administered at area under the concentration time curve 5 milligram/milliliters/minute (mg/mL/min) (maximum dose: 750 mg) through a 15 to 60 minute IV infusion Q3W for 4 cycles (each cycle of 21 days) as per investigator decision."

Trial Locations (58)

500

GSK Investigational Site, Changhua

1602

GSK Investigational Site, Florida

1900

GSK Investigational Site, La Plata

11490

GSK Investigational Site, Taipei

12200

GSK Investigational Site, Berlin

14033

GSK Investigational Site, Caen

20133

GSK Investigational Site, Milan

20141

GSK Investigational Site, Milan

22031

GSK Investigational Site, Fairfax

23007

GSK Investigational Site, Jaén

25123

GSK Investigational Site, Brescia

26121

GSK Investigational Site, Oldenburg

27003

GSK Investigational Site, Lugo

28644

GSK Investigational Site, Cheongju Chungcheongbuk-do

29010

GSK Investigational Site, Málaga

33081

GSK Investigational Site, Aviano PN

33604

GSK Investigational Site, Pessac

34376

GSK Investigational Site, Immenhausen

41014

GSK Investigational Site, Seville

44805

GSK Investigational Site, Saint-Herblain

45242

GSK Investigational Site, Cincinnati

48108

GSK Investigational Site, Pusan

51109

GSK Investigational Site, Cologne

59300

GSK Investigational Site, Valenciennes

60488

GSK Investigational Site, Frankfurt

72000

GSK Investigational Site, Le Mans

80128

GSK Investigational Site, Denver

80131

GSK Investigational Site, Napoli

87042

GSK Investigational Site, Limoges

200347

GSK Investigational Site, Craiova

407280

GSK Investigational Site, Floreşti

7500653

GSK Investigational Site, Santiago

8320000

GSK Investigational Site, Santiago

C1426ABP

GSK Investigational Site, Buenos Aires

C1012AAR

GSK Investigational Site, Ciudad Autonoma de Buenos Aire

X5004FHP

GSK Investigational Site, Córdoba

F5300COE

GSK Investigational Site, La Rioja

B2700CPM

GSK Investigational Site, Pergamino

S2000KZE

GSK Investigational Site, Rosario

J5402DIL

GSK Investigational Site, San Juan

R8500ACE

GSK Investigational Site, Viedma

14784-400

GSK Investigational Site, Barretos

60336-232

GSK Investigational Site, Fortaleza

59075-740

GSK Investigational Site, Natal

20230 -130

GSK Investigational Site, Rio de Janeiro

04014-002

GSK Investigational Site, São Paulo

29043-260

GSK Investigational Site, Vitória

00152

GSK Investigational Site, Roma

85-796

GSK Investigational Site, Bydgoszcz

90-338

GSK Investigational Site, Lodz

20-954

GSK Investigational Site, Lublin

10-357

GSK Investigational Site, Olsztyn

60-693

GSK Investigational Site, Poznan

030442

GSK Investigational Site, Bucharest

05505

GSK Investigational Site, Seoul

06351

GSK Investigational Site, Seoul

120-752

GSK Investigational Site, Seoul

08003

GSK Investigational Site, Barcelona

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY

NCT04581824 - Efficacy Comparison of Dostarlimab Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy in Participants With Metastatic Non-squamous Non-small Cell Lung Cancer (NSCLC) | Biotech Hunter | Biotech Hunter