A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

86

Participants

Timeline

Start Date

February 14, 2022

Primary Completion Date

October 31, 2027

Study Completion Date

October 31, 2027

Conditions
Mucopolysaccharidosis II
Interventions
DRUG

JR-141

IV infusion, 2.0 mg/kg/week

DRUG

Idursulfase

IV infusion

DRUG

JR-141 or Idursulfase

"The subjects who have achieved the pre-specified criteria\* are able to change the drug.~\*If a subject in Idursulfase group shows decline in their neurocognitive outcome, idursulfase can be switched to JR-141.~If a subject in JR-141 group shows decline in their peripheral outcome, JR-141 will be switched to idursulfase."

Trial Locations (29)

10032

Columbia University, New York

19104

Children's Hospital of Philadelphia, Philadelphia

55455

University of Minnesota, Minneapolis

60611

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

94609

UCSF Benioff Children's Hospital Oakland, Oakland

27599-7487

Phoenix Children's Hospital, Phoenix

University of North Carolina at Chapel Hill Medical School Wing E, Chapel Hill

Unknown

Hospital Universitario Austral, Buenos Aires

Hospital de Clínicas de Porto Alegre, Porto Alegre

Instituto de Medicina Integral Prof. Fernando Figueira - Imip, Recife

Instituto de Genética e Erros Inatos do Metabolismo, São Paulo

Fundación Cardio Infantil - Instituto de Cardiología, Bogotá

Hôpital Femme Mère Enfant, Bron

Chu De Montpellier Hopital Gui De Chauliac, Montpellier

Hôpital Armand Trousseau, Paris

Universitätsklinikum Giessen, Giessen

Universitätsklinikum Hamburg-Eppendorf, Hamburg

SphinCS GmbH, Höchheim

Universitätsmedizin Mainz, Mainz

Ha'Emek Medical Center, Afula

The Chaim Sheba Medical Center, Ramat Gan

Fondazione IRCCS San Gerardo dei Tintori, Monza

Osp. Pediatrico Bambino Gesù, IRCCS, Rome

Uniwersytecki Szpital Dziecięcy, Krakow

Hospital Sant Joan de Déu, Barcelona

Hospital Universitario Virgen del Rocio, Seville

Gazi University Medicine Faculty Hospital, Ankara

Ege University Children Hospital, Izmir

Great Ormond Street Hospital for Children NHS Trust - Metabolic Medicine, London

Sponsors
All Listed Sponsors
lead

JCR Pharmaceuticals Co., Ltd.

INDUSTRY

NCT04573023 - A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II (STARLIGHT) | Biotech Hunter | Biotech Hunter