HORIZON: A Phase II Study to Evaluate the Safety and Efficacy of Two Doses of GT005

PHASE2TerminatedINTERVENTIONAL
Enrollment

255

Participants

Timeline

Start Date

September 28, 2020

Primary Completion Date

June 10, 2024

Study Completion Date

June 10, 2024

Conditions
Dry Age-related Macular Degeneration
Interventions
DRUG

GT005

GT005 is a recombinant, non-replicating AAV2 expressing human complement factor I (CFI). GT005 was administered as a single time subretinal injection into the study eye of subjects allocated to one of the two GT005 doses.

Trial Locations (62)

2000

Sydney Hospital and Sydney Eye Hospital, Sydney

3002

The University of Melbourne - The Centre for Eye Research Australia (CERA), Melbourne E.

10032

Columbia University Medical Center, New York

13008

Centre Paradis Monticelli, Marseille

14620

Retina Associates of Western New York, Rochester

16507

Erie Retinal Surgery ,INC, Erie

19107

Mid Atlantic Retina - Wills Eye Hospital, Philadelphia

21000

CHU Dijon - Hopital Mitterrand, Dijon

21209

The Retina Care Center, Baltimore

23562

Universitaetsklinikum Schleswig-Holstein - Campus Lübeck, Lübeck

27705

Duke Eye Center, Durham

28046

Clinica Baviera, Madrid

29169

Palmetto Retina Center, West Columbia

30060

Georgia Retina PC, Marietta

30909

Southeast Retina Center, Augusta

31008

Clinica Universidad de Navarra - Pamplona, Pamplona

32607

VitreoRetinal Associates, P.A., Gainesville

33064

Rand Eye Institute, Deerfield Beach

33136

Bascom Palmer Eye Institute, Miami

33711

Retina Vitreous Associates of Florida, St. Petersburg

37922

Southeastern Retina Associates, PC, Knoxville

38138

Charles Retina Institute, Germantown

40549

Internationale Innovative Ophthalmochirurgie, Düsseldorf

44093

CHU de Nantes - Hôtel-Dieu, Nantes

44195

Cleveland Clinic, Cleveland

45242

Cincinnati Eye Institute, Cincinnati

46290

Midwest Eye Institute Northside, Indianapolis

48073

Associated Retinal Consultants PC, Royal Oak

48439

Retina Associates of Michigan, Grand Blanc

50266

Wolfe Eye Clinic, West Des Moines

53127

Universitätsklinikum Bonn, Bonn

60452

University Retina Macula Associates PC, Lemont

60657

Illinois Retina Associates, Chicago

66204

Retina Associates, LLC, Shawnee Mission

72076

Universitaetsklinikum Tuebingen, Tübingen

75231

Retina Foundation of the Southwest, Dallas

Texas Retina Associates (Dallas), Dallas

77384

Retina Consultants of Houston, The Woodlands

77401

Retina Consultants of Houston-TMC, Bellaire

78240

Retinal Consultants of San Antonio, San Antonio

78705

Austin Research Center for Retina, PLLC, Austin

81303

Southwest Retina Research Center, Durango

84107

Rocky Mountain Retina Consultants, Salt Lake City

85053

Retinal Research Institute (retina consultants of AZ), Phoenix

89502

Sierra Eye Associates, Reno

90211

Retina Vitreous Associates Medical Group, Beverly Hills

92064

Retina Consultants of San Diego, Poway

92835

Retina Consultants of Orange County, Fullerton

94040

Northern California Retina Vitreous Associates, Mountain View

94303

Byers Eye Institute at Stanford, Palo Alto

95817

University of California (UC) Davis Medical Group Eye Center, Sacramento

97239

Casey Eye Institute - OHSU, Portland

97401

Oregon Retina, Eugene

98383

Retina Center Northwest, Silverdale

02114

Ophthalamic Consultants of Boston (OCB), Boston

98104-2499

Department of Ophthalmology UW Medicine, Seattle

85-631

Oftalmika Spolka z ograniczona odpowiedzialnoscia, Bydgoszcz

08035

Instituto de microcirugía ocular, Barcelona

EC1V 2PD

Moorfields Eye Hospital - NHS Foundation Trust, London

W1G 7LB

Retina Clinic London, London

OX3 9DU

John Radcliffe Hospital, Oxford

SR2 9HP

Sunderland Eye Infirmary, Sunderland

Sponsors
All Listed Sponsors
collaborator

Novartis Pharmaceuticals

INDUSTRY

lead

Gyroscope Therapeutics Limited

INDUSTRY