Testing the Addition of the Anti-cancer Drug, Tazemetostat, to the Usual Treatment (Dabrafenib and Trametinib) for Metastatic Melanoma That Has Progressed on the Usual Treatment

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

August 19, 2021

Primary Completion Date

November 1, 2025

Study Completion Date

November 1, 2025

Conditions
Clinical Stage IV Cutaneous Melanoma AJCC v8Metastatic Melanoma
Interventions
PROCEDURE

Biopsy Procedure

Undergo tumor biopsy

PROCEDURE

Computed Tomography

Undergo CT scan

DRUG

Dabrafenib Mesylate

Given PO

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

DRUG

Tazemetostat Hydrobromide

Given PO

DRUG

Trametinib Dimethyl Sulfoxide

Given PO

Trial Locations (17)

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

27157

RECRUITING

Wake Forest University Health Sciences, Winston-Salem

30322

RECRUITING

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

ACTIVE_NOT_RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

ACTIVE_NOT_RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

53718

RECRUITING

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison

53792

RECRUITING

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

60611

RECRUITING

Northwestern University, Chicago

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH