A Phase 1b Study of T-DXd Combinations in HER2-low Advanced or Metastatic Breast Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

138

Participants

Timeline

Start Date

December 17, 2020

Primary Completion Date

August 16, 2023

Study Completion Date

December 4, 2025

Conditions
Metastatic Breast Cancer
Interventions
DRUG

Trastuzumab deruxtecan

T-DXd: administered as an IV infusion

DRUG

Durvalumab

Durvalumab: administered as an IV infusion

DRUG

Paclitaxel

Paclitaxel: administered as an IV infusion

DRUG

Capivasertib

Capivasertib: administered orally

DRUG

Anastrozole

Anastrozole: administered orally

DRUG

Fulvestrant

Fulvestrant: administered as an IM injection

DRUG

Capecitabine

Capecitabine: administered orally

Trial Locations (37)

100

Research Site, Taipei

114

Research Site, Taipei

235

Research Site, Taipei

333

Research Site, Taoyuan District

1340

Research Site, Ottignies

2145

Research Site, Westmead

2650

Research Site, Edegem

3000

Research Site, Leuven

3002

Research Site, East Melbourne

10029

Research Site, New York

10065

Research Site, New York

10604

Research Site, Harrison

11217

Research Site, Taipei

11553

Research Site, Uniondale

11725

Research Site, Commack

27514

Research Site, Chapel Hill

37404

Research Site, Chattanooga

38138

Research Site, Germantown

40443

Research Site, Taichung

64710

Research Site, Monterrey

76104

Research Site, Fort Worth

82445

Research Site, Kaohsiung City

94805

Research Site, Villejuif

115478

Research Site, Moscow

143442

Research Site, Moscow

199226

Research Site, Saint Petersburg

74605-070

Research Site, Goiânia

90035-003

Research Site, Porto Alegre

90110-270

Research Site, Porto Alegre

03102-002

Research Site, São Paulo

04543-000

Research Site, São Paulo

V1Y 5L3

Research Site, Kelowna

G1J 1Z4

Research Site, Québec

03080

Research Site, Seoul

03722

Research Site, Seoul

05505

Research Site, Seoul

06351

Research Site, Seoul

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo Co., Ltd.

INDUSTRY

collaborator

Daiichi Sankyo Company, Limited

UNKNOWN

lead

AstraZeneca

INDUSTRY