Study to Assess the Effect on Glucose Homeostasis of Two Dose Levels of AZD9567, Compared to Prednisolone, in Adults With Type 2 Diabetes

PHASE2CompletedINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

November 26, 2020

Primary Completion Date

June 9, 2021

Study Completion Date

June 9, 2021

Conditions
Diabetes Mellitus, Type 2
Interventions
DRUG

AZD9567

Participants will receive 72 mg/day (oral suspension) of AZD9567 for 3 consecutive days of each treatment period in Cohort 1 and 40 mg/day for 3 consecutive days of each treatment period in Cohort 2.

DRUG

Prednisolone

Participants will receive 40 mg/day of prednisolone for 3 consecutive days of each treatment period in Cohort 1, 20 mg/day of prednisolone for 3 consecutive days of each treatment period in Cohort 2, and 5 mg/day prednisolone for 3 consecutive days of each treatment period in Cohort 3.

OTHER

Placebo

Participants will receive placebo for 3 consecutive days of each treatment period in Cohort 3.

Trial Locations (3)

41460

Research Site, Neuss

55116

Research Site, Mainz

68167

Research Site, Mannheim

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Parexel

INDUSTRY

lead

AstraZeneca

INDUSTRY