Phase 1a/1b Study of Aplitabart (IGM-8444) Alone or in Combination in Participants with Relapsed, Refractory, or Newly Diagnosed Cancers

PHASE1TerminatedINTERVENTIONAL
Enrollment

272

Participants

Timeline

Start Date

September 23, 2020

Primary Completion Date

January 20, 2025

Study Completion Date

January 20, 2025

Conditions
Solid TumorColorectal CancerNon Hodgkin LymphomaSarcomaChondrosarcomaSmall Lymphocytic LymphomaChronic Lymphocytic LeukemiaAcute Myeloid Leukemia
Interventions
DRUG

Aplitabart (IGM-8444)

DR5 Agonist Investigational Drug

DRUG

FOLFIRI

Chemotherapy Regimen

DRUG

Bevacizumab (and approved biosimilars)

Targeted Therapy

DRUG

Birinapant

SMAC-mimetic Investigational Drug

DRUG

Venetoclax

Targeted Therapy

DRUG

Gemcitabine

Chemotherapy

DRUG

Docetaxel

Chemotherapy

DRUG

Azacitidine

Chemotherapy

Trial Locations (58)

2145

Westmead, Westmead

2500

Southern Medical Day Care Centre, Wollongong

2747

Napean Cancer Care, Kingswood

3052

Peter MacCallum Cancer Centre, Melbourne

5011

Queen Elizabeth Hospital, Woodville South

13620

Gachon University Gil Hospital, Gyeonggi-do

Seoul National University Bundang Hospital, Gyeonggi-do

21000

Centre Georges Francois Leclerc, Dijon

21044

Maryland Oncology Hematology, PA - Columbia, Columbia

22031

Inova Schar Cancer Institute, Fairfax

Virginia Cancer Specialists, Fairfax

23502

US Oncology- Virginia Oncology - Norfolk, Norfolk

28027

Clinica Universidad de Navarra, Madrid

28040

Madrid FJD, Madrid

28050

Madrid CIOCC - HM Universitario Sanchinnarro, Madrid

32224

Mayo Clinic, Jacksonville

32746

FL Cancer Specialists - Lake Mary, Lake Mary

33028

Memorial Cancer Institute, Pembroke Pines

33076

Institut Bergonié, Bordeaux

34232

Florida Cancer Specialists, Sarasota

37203

SCRI - Tennessee, Nashville

40241

Norton Cancer Institute, Louisville

44718

Gabrail Cancer Research, Canton

44800

Institut de Cancérologie de l'Ouest, Saint-Herblain

46804

Fort Wayne Medical Oncology and Hematology, Fort Wayne

49546

START Midwest, Grand Rapids

55404

Minnesota Oncology - Minneapolis Clinic, Minneapolis

55905

Mayo Clinic, Minneapolis

63110

Washington University School of Medicine, St Louis

70121

Ochsner Cancer, Jefferson

73104

Stephenson Cancer Center, Oklahoma City

75010

Saint Louis Hospital, Paris

75230

Mary Crowley Cancer Research, Dallas

75246

US Oncology - Dallas, Dallas

75702

Texas Oncology - Tyler, Tyler

76104

US Oncology- Texas Oncology - Fort Worth, Fort Worth

77030

The University of Texas, MD Anderson, Houston

78217

Texas Oncology - San Antonio Northeast, San Antonio

78705

Texas Oncology - Austin, Austin

80218

Rocky Mountain Cancer Centers, Denver

SCRI at Healthone, Denver

85054

Mayo Clinic, Phoenix

90033

USC Norris, Los Angeles

90404

UCLA, Los Angeles

90720

Cancer and Blood Specialty Clinic (CBSC), Los Alamitos

91010

City of Hope Comprehensive Cancer Center, Duarte

92868

UC Irvine Manchester Pavilion, Orange

94143

UCSF, San Francisco

94805

Gustave Roussy, Villejuif

97213

Providence Portland Medical Center, Portland

98109

Seattle Cancer Alliance - Fred Hutch, Seattle

06510

Yale Cancer Center, New Haven

QLD 4215

Tasman Health, Southport

06351

Samsung Medical Center, Seoul

03080

Asan Medical Center, Seoul

Seoul National University Hospital, Seoul

Unknown

Severance Hospital - Yonsei Cancer Center, Soeul

08035

Vall d'Hebron Institut d'Oncologia, Barcelona

Sponsors
All Listed Sponsors
lead

IGM Biosciences, Inc.

INDUSTRY