PF-07104091 as a Single Agent and in Combination Therapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

154

Participants

Timeline

Start Date

September 16, 2020

Primary Completion Date

March 30, 2026

Study Completion Date

March 30, 2026

Conditions
Small Cell Lung CancerOvarian CancerBreast Cancer
Interventions
DRUG

PF-07104091 monotherapy dose escalation

PF-07104091 will be administered orally

DRUG

PF-07104091 + palbociclib + fulvestrant

PF-07104091 will be administered orally in combination with palbociclib and fulvestrant

DRUG

PF-07104091 + palbociclib + letrozole

PF-07104091 will be administered orally in combination with palbociclib and letrozole

DRUG

PF-07104091 monotherapy dose expansion (ovarian)

PF-07104091 will be administered orally

DRUG

PF-07104091 monotherapy dose expansion (SCLC)

PF-07104091 will be administered orally

DRUG

PF-07104091 + Fulvestrant (post CDK4/6)

PF-07104091 will be administered orally in combination with fulvestrant

DRUG

PF-0704091 + Fulvestrant (post CDK4/6)

PF-07104091 + fulvestrant (post 4/6) dose expansion

Trial Locations (46)

1125

Fundación Cenit Para La Investigación En Neurociencias, CABA

4004

Complex Oncology Center - Plovdiv EOOD, Plovdiv

5400

Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan, San Juan

6300

Specialized Hospital for Active Treatment of Oncology - Haskovo, Haskovo

9700

Complex Oncology Center - Shumen, Shumen

10016

Laura & Isaac Perlmutter Cancer Center - NYU ACC, New York

Laura & Isaac Perlmutter Cancer Center at NYU Langone Health, New York

NYU Langone Medical Center (Tisch Hospital), New York

10022

MSK Rockefeller Outpatient Pavilion, New York

10065

Memorial Sloan Kettering Cancer Center, New York

10601

White Plains Hospital, White Plains

10604

Memorial Sloan Kettering Westchester, Harrison

11101

Memorial Sloan Kettering Cancer Center (IDS Pharmacy), Long Island City

11501

NYU Langone Hospital - Long Island, Mineola

Perlmutter Cancer Center at NYU Langone Hospital - Long Island, Mineola

22903

University of Virginia Cancer Center, Charlottesville

22908

University of Virginia Health System, Charlottesville

22911

UVA Breast Care Center, Charlottesville

40202

Norton Cancer Institute Downtown, Louisville

Norton Cancer Institute Pharmacy, Downtown Pharmacy, Louisville

Norton Cancer Institute, Downtown, Louisville

Norton Hospital, Louisville

40207

Norton Cancer Institute, St. Matthews, Louisville

Norton Women's and Children's Hospital (St. Matthews), Louisville

40217

Norton Cancer Institute, Audubon, Louisville

Norton Hospital (Audubon), Louisville

40241

Norton Brownsboro Hospital, Louisville

Norton Cancer Institute, Brownsboro Campus, Louisville

49546

START Midwest, Grand Rapids

50309

Des Moines Oncology Research Association, Des Moines

Medical Oncology & Hematology Associates DBA Mission Cancer and Blood, Des Moines

50314

Medical Oncology & Hematology Associates DBA Mission Cancer and Blood, Des Moines

50325

Medical Oncology & Hematology Associates DBA Mission Cancer and Blood, Clive

77030

University of Texas MD Anderson Cancer Center, Houston

130000

Jilin Province Cancer Hospital, Changchun

130021

The First Hospital of Jilin University, Changchun

200032

Fudan University Shanghai Cancer Center, Shanghai

300060

Tianjin Medical University Cancer Institute & Hospital, Tianjin

02114

Massachusetts General Hospital, Boston

02115

Brigham & Women's Hospital, Boston

02215

Dana Farber Cancer Institute, Boston

02459

Dana-Farber Cancer Institute - Chestnut Hill, Newton

07748

Memorial Sloan Kettering Monmouth, Middletown

C1426AGE

Centro Oncologico Korben, Caba

277-8577

National Cancer Center Hospital East, Kashiwa

135-8550

The Cancer Institute Hospital of JFCR, Koto

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Pfizer

INDUSTRY

NCT04553133 - PF-07104091 as a Single Agent and in Combination Therapy | Biotech Hunter | Biotech Hunter