Urea Therapy for Hyponatremia in Subarachnoid Hemorrhage

NAActive, not recruitingINTERVENTIONAL
Enrollment

52

Participants

Timeline

Start Date

December 3, 2020

Primary Completion Date

December 3, 2024

Study Completion Date

August 1, 2025

Conditions
HyponatremiaSubarachnoid HemorrhageSIADH
Interventions
DRUG

Urea

"the experimental group will be treated during 5 days by urea dose per administration : 1g / kg / 24 hours in 2 or 3 doses morning, noon and evening (dose adjustment of urea according to weight)~If hyponatremia persists beyond D8 after initiation of the study treatment (urea or placebo), that is to say after the date of the collection of the primary endpoint, it will be possible to introduce corticosteroids (fludrocortisone or others). These treatments will be collated.~If during patient monitoring the serum sodium exceeds 145 mmol / L, treatment should no longer be administered."

OTHER

PLACEBO

the control group will be treated during 5 days by ergytonyl dose per administration : 5mL

Trial Locations (1)

38043

University Hospital Grenoble, Grenoble

All Listed Sponsors
lead

University Hospital, Grenoble

OTHER