52
Participants
Start Date
December 3, 2020
Primary Completion Date
December 3, 2024
Study Completion Date
August 1, 2025
Urea
"the experimental group will be treated during 5 days by urea dose per administration : 1g / kg / 24 hours in 2 or 3 doses morning, noon and evening (dose adjustment of urea according to weight)~If hyponatremia persists beyond D8 after initiation of the study treatment (urea or placebo), that is to say after the date of the collection of the primary endpoint, it will be possible to introduce corticosteroids (fludrocortisone or others). These treatments will be collated.~If during patient monitoring the serum sodium exceeds 145 mmol / L, treatment should no longer be administered."
PLACEBO
the control group will be treated during 5 days by ergytonyl dose per administration : 5mL
University Hospital Grenoble, Grenoble
University Hospital, Grenoble
OTHER