CRAFT: The NCT-PMO-1602 Phase II Trial

PHASE2CompletedINTERVENTIONAL
Enrollment

72

Participants

Timeline

Start Date

October 13, 2021

Primary Completion Date

December 30, 2024

Study Completion Date

December 30, 2024

Conditions
Metastatic or Locally Advanced Malignancies
Interventions
DRUG

Vemurafenib

960 mg twice daily during run-in Phase, followed by 720 mg twice daily

DRUG

Cobimetinib

60 mg once daily

DRUG

Atezolizumab

840 mg every 2 weeks

DRUG

Trastuzumab

8 mg per kilogram of body weight as a loading dose, followed by 6 mg per kilogram every 3 weeks

DRUG

Pertuzumab

840 mg as a loading dose, followed by 420 mg intravenously every 3 weeks

DRUG

Alectinib

600 mg twice daily

DRUG

Ipatasertib

400 mg once daily

DRUG

Atezolizumab

1200 mg every 3 weeks

DRUG

Atezolizumab

1200 mg in the first cycle, followed by 840 mg every 3 weeks

DRUG

Atezolizumab

1,200 mg every 3 weeks

DRUG

Inavolisib

9 mg once daily

Trial Locations (9)

12203

Charité - Universitätsmedizin Berlin, Berlin

23538

Universitätsklinikum Schleswig-Holstein, Lübeck

55131

Universitätsmedizin der Johannes Gutenberg- Universität Mainz, Mainz

69120

Nationales Centrum für Tumorerkrankungen (NCT), Heidelberg

72076

Universitätsklinikum Tübingen, Medizinische Klinik I, Tübingen

79106

Universitätsklinikum Freiburg, Freiburg im Breisgau

81675

Klinikum Rechts der Isar der TU München, München

97080

Universitätsklinikum Würzburg, Interdisziplinäres Studienzentrum mit ECTU, Würzburg

01307

Nationales Centrum für Tumorerkrankungen (NCT), Dresden

All Listed Sponsors
lead

German Cancer Research Center

OTHER

NCT04551521 - CRAFT: The NCT-PMO-1602 Phase II Trial | Biotech Hunter | Biotech Hunter