Use Of A Response-Adapted Ruxolitinib-Containing Regimen For The Treatment Of Hemophagocytic Lymphohistiocytosis

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

July 13, 2021

Primary Completion Date

November 30, 2025

Study Completion Date

August 31, 2026

Conditions
Hemophagocytic Lymphohistiocytosis
Interventions
DRUG

Ruxolitinib

Given orally (PO) or per nasogastric tube (NGT) twice a day for 8 weeks

DRUG

Dexamethasone

Given intravenously (IV) or orally (PO) twice a day for 8 weeks

DRUG

Etoposide

Given intravenously (IV) once a week for 8 weeks

Trial Locations (13)

11040

Cohen Children's Medical Center, New Hyde Park

19104

Children's Hospital of Philadelphia, Philadelphia

20010

Children's National Medical Center, Washington D.C.

21287

John Hopkins University, Baltimore

28203

Levine Children's Hospital, Charlotte

38105

St. Jude Children's Research Hospital, Memphis

53226

Children's Wisconsin/Medical College of Wisconsin, Milwaukee

75235

University of Texas Southwestern Medical Center, Dallas

77030

Texas Children's Hospital, Houston

85016

Phoenix Children's Hospital, Phoenix

92868

Children's Hospital of Orange County, Orange

94158

University of California San Francisco, San Francisco

02215

Dana-Farber Cancer Institute, Boston

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

collaborator

North American Consortium for Histiocytosis

OTHER

collaborator

Cures Within Reach

OTHER

lead

St. Jude Children's Research Hospital

OTHER