Efficacy of Conservative Treatment of Functional Defecatory Disorders in Females With Pelvic Organ Prolapse

PHASE3RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

July 1, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

May 31, 2026

Conditions
Pelvic Floor ProlapseFunctional ConstipationRectocele
Interventions
PROCEDURE

Biofeedback therapy

Biofeedback therapy is a procedure when the patient is taught to make proper squeezing by adequate increase of intra-abdominal and rectal pressures and relaxation of the muscles of the pelvic floor. This procedure is widely described and is to be performed with the use of devices registered for this purpose Urostim and WPM Solar, MMS, the Netherlands

PROCEDURE

Tibial neuromodulation

TNM is a standard procedure that is previously described as an effective method to treat functional insufficiency of the anal sphincter. It acts on the lumbosacral nerve plexus with an electric current through the posterior tibial nerve of one of the patient's limbs. For the study purpose a registered device for electric therapy (BioBravo, MTR Plus Vertriebs GmbH, Germany) is to be used.

BEHAVIORAL

Pelvic floor muscles training

"PFMT is a complex of 5 exercises aimed to make functional training of pelvic floor muscles. This complex does not require additional equipment. It may be performed at home. The patients will be trained to perform this complex of exercises by a healthcare provider.~The complex of physical therapy consists of a single basic exercise for training coordinated muscle tension of abdominal wall and relaxation of the pelvic floor muscles, and 4 exercises to increase the contractility of pelvic floor muscles without additional involvement of the muscles of the abdominal wall. This allows to coordinate and consciously control the contraction and relaxation of the pelvic diaphragm. Initial course of training is 10 working days. Than patients continue the intervention for 6 months at home with online monitoring of the correctness and regularity of training."

BEHAVIORAL

Diet modification

Diet modification play an important role in the regulation of colonic transit and defecation. Dietary factors may act through faecal bulk by additional stimulation of mechanoreceptors of the rectum. At the same time, adequate intake of vitamins (for example, B12) may improve electric conductivity of nerves and thus impact the tone of pelvic floor muscles. Among other factors known to affect functional state of pelvic floor muscles and colonic transit are dietary fibers, adequate intake of water, regular meal intake. For the study purposes, it is planned to provide standard recommendation based on the national recommended daily allowances according to patients' sex, age and physical activity level.

Trial Locations (2)

115446

RECRUITING

"Federal State Budgetary Scientific Institution Federal Research Centre of Nutrition, Biotechnology", Moscow

Unknown

RECRUITING

Federal Research Center of Coloproctology, Moscow

All Listed Sponsors
collaborator

State Scientific Centre of Coloproctology, Russian Federation

OTHER_GOV

collaborator

Ministry of Health, Russian Federation

OTHER_GOV

collaborator

Ministry of Science and Higher Education, Russian Federation

UNKNOWN

lead

"Federal State Budgetary Scientific Institution Federal Research Centre of Nutrition, Biotechnology"

OTHER