349
Participants
Start Date
December 22, 2020
Primary Completion Date
December 22, 2025
Study Completion Date
December 22, 2025
Pembrolizumab
Pembrolizumab 200 mg once every 3 weeks for a maximum of 35 cycles or until disease progression, death, unacceptable toxicity, or the Investigator's or the patient's decision to stop.
Pembrolizumab and Chemotherapy drugs
"An induction therapy followed by a maintenance therapy.~4 induction cycles every 3 weeks associating, on the first day of each cycle:~* Cisplatin 75mg/m² or carboplatin AUC 5mg/mL/min, pemetrexed 500mg/m² and pembrolizumab 200mg for non squamous NSCLC.~* Carboplatin AUC 6mg/mL/min, paclitaxel 200mg/m² and pembrolizumab 200mg for squamous NSCLC.~After the 4 induction cycles, a maintenance therapy will be possible for patients who are responding or stable:~* Non squamous NSCLC: pembrolizumab and pemetrexed combination or either drug as monotherapy.~* Squamous NSCLC: pembrolizumab monotherapy.~For pembrolizumab: treatment may be continued for a maximum of 35 cycles or until disease progression, death, unacceptable toxicity, or following the Investigator's or the patient's decision to stop.~For pemetrexed, treatment may be continued until disease progression, death, unacceptable toxicity, or following the Investigator's or the patient's decision to stop."
Institut Paoli-Calmette, Marseille
Hôpital Européen Marseille, Marseille
CH du Pays d'Aix, Aix-en-Provence
CHU MARSEILLE_ Hopital Nord, Marseille
Centre de lutte contre le cancer - Centre François Baclesse, Caen
Centre Hospitalier de Cornouaille, Quimper
CHRU de Brest, Brest
CHU Bordeaux - Hôpital du Haut Levêque, Pessac
CHU RENNES - Hôpital Pontchailloux, Rennes
SAINT-PRIEST EN JAREZ - Institut de Cancérologie de la Loire, Saint-Priest-en-Jarez
Chu Angers, Angers
CH de Lorient - Hôpital du Scorff, Lorient
Institut de Cancérologie Strasbourg Europe, Strasbourg
Centre Léon Berard, Lyon
Ch Villefranche Sur Saone, Villefranche-sur-Saône
Centre Hospitalier Métropole Savoie, Chambéry
CH d'Annecy-genevois, Pringy
APHP - Hôpital Cochin, Paris
CHU ROUEN - Hôpital Charles Nicolle, Rouen
Saint Aubin Les Elbeuf, Saint-Aubin-lès-Elbeuf
CH MEAUX, Meaux
CHU AMIENS - Hôpital Sud, Amiens
Hôpital d'Instruction des Armées Toulon - Saint Anne, Toulon
CH La Roche Sur Yon - CHD Les Oudairies, La Roche-sur-Yon
Chu Dupuytren, Limoges
CH Intercommunal de Créteil, Créteil
Institut Gustave Roussy, Villejuif
CH La Réunion - Site Félix Guyon, Saint-Denis
CHU La Réunion - Groupe Hospitalier Sud, Saint-Pierre
Groupe Francais De Pneumo-Cancerologie
OTHER
University Hospital, Brest
OTHER