Li-Fraumeni & TP53 (LiFT UP): Understanding and Progress

RecruitingOBSERVATIONAL
Enrollment

1,500

Participants

Timeline

Start Date

September 15, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Li-Fraumeni SyndromeTP53 Gene MutationHereditary Cancer SyndromeClonal HematopoiesisMosaicism
Interventions
GENETIC

Data and Specimen Collection

"* Provide research team and access to relevant medical records~* Answer short questionnaires periodically~* Consider consenting to other optional parts of the research such as:~* Providing up to 3 tubes (15ml) of blood at or near the time of consent, as approved by treating physician (optional).~* Provide a saliva sample (optional).~* Provide eyebrow hairs for analysis of DNA from the bulb (15-20 eyebrow plucks) (optional).~* Provide permission for obtainment of stored tissue specimens from cancer or pre-cancer surgeries or biopsies from the pathology departments where they have been stored (optional).~* Consider inviting relatives to join the study (optional)."

Trial Locations (3)

02115

RECRUITING

Boston Children's Hospital, Boston

02215

RECRUITING

Brigham and Women's Hospital, Boston

RECRUITING

Judy E. Garber, Boston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

City of Hope Medical Center

OTHER

collaborator

Baylor College of Medicine

OTHER

lead

Dana-Farber Cancer Institute

OTHER