A Study of Atezolizumab Plus Tiragolumab in Combination With Paclitaxel and Cisplatin Compared With Paclitaxel and Cisplatin as First-Line Treatment in Participants With Unresectable Locally Advanced, Unresectable Recurrent, or Metastatic Esophageal Carcinoma

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

461

Participants

Timeline

Start Date

October 30, 2020

Primary Completion Date

February 13, 2023

Study Completion Date

January 31, 2026

Conditions
Esophageal Cancer
Interventions
DRUG

Atezolizumab

Atezolizumab at a fixed dose of 1200 milligrams (mg) administered by intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab at a fixed dose of 600 mg administered by IV infusion every Q3W on Day 1 of each 21-day cycle.

DRUG

Paclitaxel

Paclitaxel 175 mg/m\^2 administered by IV infusion on Day 1 of each 21-day cycle for 6 cycles.

DRUG

Cisplatin

Cisplatin 60-80 mg/m\^2 administered by IV infusion on Day 1 of each 21-day cycle for 6 cycles.

DRUG

Atezolizumab Matching Placebo

Atezolizumab matching placebo administered by IV infusion, Q3W on Day 1 of each 21-day cycle.

DRUG

Tiragolumab Matching Placebo

Tiragolumab matching placebo administered by IV infusion, Q3W on Day 1 of each 21-day cycle.

Trial Locations (67)

10048

National Taiwan University Hospital, Zhongzheng Dist.

10330

Chulalongkorn Hospital, Bangkok

10400

Rajavithi Hospital, Bangkok

Ramathibodi Hospital, Bangkok

10408

National Cancer Center, Goyang-si

10700

Siriraj Hospital, Bangkok

12345

Anhui Province Cancer Hospital, Hefei

13605

Seoul National University Bundang Hospital, Seongnam-si

41404

Kyungpook National University Chilgok Hospital, Daegu

90110

Songklanagarind Hospital, Songkhla

100142

Beijing Cancer Hospital, Beijing

110042

Liaoning Provincial Cancer Hospital, Shengyang

112201

Taipei Veterans General Hospital, Taipei

130021

the First Hospital of Jilin University, Changchun

132013

Jilin Cancer Hospital, Changchun

150081

Harbin Medical University Cancer Hospital, Harbin

200000

Shanghai Chest Hospital, Shanghai

200032

Zhongshan Hospital Fudan University, Shanghai

200120

Fudan University Shanghai Cancer Center, Shanghai

210029

Jiangsu Province Hospital of Chinese Medicine, Nanjing

211100

Jiangsu Cancer Hospital, Nanjing

214122

Affiliated Hospital of Jiangnan University(Wuxi Fourth People's Hospital ), Wuxi

222002

The First People's Hospital of Lian Yun Gang, Lianyungang

225001

Northern Jangsu People's Hospital, Yangzhou

226361

Nan Tong Tumor Hospital, Nantong

230001

Anhui Provincial Hospital, Anhui

230601

The Second Affiliated Hospital of Anhui Medical University, Hefei

276034

Linyishi Cancer Hospital, Linyi

300060

Tianjin Cancer Hospital, Tianjin

310022

Zhejiang Cancer Hospital, Hangzhou

350014

Fujian Cancer Hospital, Fuzhou

361003

The First Affiliated Hospital of Xiamen University, Xiamen

361004

Zhongshan Hospital Xiamen University, Xiamen

404000

Chongqing Sanxia Central Hospital, Chongqing

410013

Hunan Cancer Hospital, Changsha

430022

Wuhan Union Hospital Tongji Medical College, Huazhong University of Science and Technology, Wuhan

430079

Hubei Cancer Hospital, Wuhan

450008

Henan Cancer Hospital, Zhengzhou

450052

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

455000

Anyang Tumor Hosptial, Anyang

510000

The First People's Hospital of Foshan, Foshan

510515

Southern Medical University Nanfang Hospital, Guangdong Province Guangzhou City

515041

Cancer Hospital of Shantou University Medical College, Shantou

610041

Sichuan Provincial Cancer Hospital, Chengdu

West China Hospital, Sichuan University, Chengdu

629000

Suining Central Hospital, Suining

710038

The Second Affiliated Hospital of The Fourth Military Medical University (Tangdu Hospital), Xi'an

710061

First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an

730000

Gansu Province People Hospital, Lanzhou

Unknown

Beijing Luhe Hospital Capital Medical University, Beijing

Fujian Provincial Hospital, Fuzhou

Huai'an First People's Hospital, Huai'an

The Second People's Hospital of Huai'an, Huai'an

Affiliated Hopsital of Jining Medical University, Jining

Weifang People's Hospital, Weifang

Xiangyang Central Hospital, Xiangyang

The First Affiliated Hospital of Xinxiang Medical University, Xinxiang

Xuzhou Central Hospital, Xuzhou

Queen Mary Hospital, Hong Kong

Prince of Wales Hosp, Shatin

Chang Gung Medical Foundation - Kaohsiung, Kaohisung

067020

Affiliated Hospital of Chengde Medical University, Chengde

03722

Severance Hospital, Yonsei University Health System, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08308

Korea University Guro Hospital, Seoul

00704

National Cheng Kung University Hospital, Tainan City

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY