An Open-Label Multiple Dose Study of RZ358 in Patients With Congenital Hyperinsulinism

PHASE2CompletedINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

February 24, 2020

Primary Completion Date

April 5, 2022

Study Completion Date

August 19, 2022

Conditions
Congenital Hyperinsulinism
Interventions
DRUG

RZ358 Sequential Group Cohort 1

IV infusion for 8 weeks (3 mg/kg bi-weekly for 8 weeks)

DRUG

RZ358 Sequential Group Cohort 2

IV infusion for 8 weeks (6 mg/kg bi-weekly for 8 weeks)

DRUG

RZ358 Sequential Group Cohort 3

IV infusion for 8 weeks (9 mg/kg bi-weekly for 8 weeks)

DRUG

RZ358 Sequential Group Cohort 4

IV infusion for 8 weeks (bi-weekly fixed dose-titration from 3 to 9 mg/kg for the first 4 weeks, followed by a fixed 9 mg/kg dose amount thereafter for the remaining 4 weeks)

Trial Locations (17)

5000

Odense University Hospital, Odense

9010

"Medical University of Varna UMHAT St. Marina", Varna

19104

The Children's Hospital of Philadelphia, Philadelphia

21070

SBÜ Gazi Yaşargil Eğitim ve Araştirma Hastanesi, Kayapınar

39120

Magdeburg University Clinic Center (Otto-von-Guericke Universität), Magdeburg

76104

Cook Children's Medical Center, Fort Worth

90000

Hadassah Har Hazofim MC - Division of Pediatric Endocrinology, Jerusalem

117036

Endocrinology research center, Moscow

5265601

Edmond & Lilly Safra's Children Hospital, Ramat Gan

Unknown

"SHAT Children diseases Prof. Dr. Ivan Mitov", Sofia

Adana Cukurova University Balcalı Hospital, Sarıçam

Erzurum City Hospital, Yakutiye

Great Ormond Street Hospital, London

H4A 3J1

Research Institute of the McGill University Health Centre, Monteral

0122

"LTD Pediatric Surgery Centre", Tbilisi

08035

Hospital Universitari Vall d' Hebron, Barcelona

06800

Hacettepe University, Çankaya

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Rezolute

OTHER