30
Participants
Start Date
September 1, 2021
Primary Completion Date
January 31, 2025
Study Completion Date
January 31, 2025
Active Vagus Nerve Stimulation
Stimulation of the vagus nerve that is paired with upper limb rehabilitation. VNS stimulation as described in the current study consists of 0.5 second trains of 0.8 mA; 100 µsec biphasic pulses at 30 Hz. Stimulation trains are delivered only during rehabilitation.
Placebo Vagus Nerve Stimulation
During Phase 1 of the study, the placebo group will receive a minimal amount of stimulation that fails to sufficiently activate the nerve, unknown to the participant and therapists. All participants will receive active stimulation during the Phase 2 open-label portion of the study.
RECRUITING
Baylor Scott & White Institute for Rehabilitation, Dallas
Lead Sponsor
The University of Texas at Dallas
OTHER
University of Texas Southwestern Medical Center
OTHER
National Institute of Neurological Disorders and Stroke (NINDS)
NIH
Baylor Research Institute
OTHER