Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

42

Participants

Timeline

Start Date

December 20, 2021

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Advanced Head and Neck Squamous Cell CarcinomaAdvanced Hypopharyngeal Squamous Cell CarcinomaAdvanced Laryngeal Squamous Cell CarcinomaAdvanced Oral Cavity Squamous Cell CarcinomaAdvanced Oropharyngeal Squamous Cell CarcinomaClinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8Stage III Hypopharyngeal Carcinoma AJCC v8Stage III Laryngeal Cancer AJCC v8Stage III Lip and Oral Cavity Cancer AJCC v8Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IVA Hypopharyngeal Carcinoma AJCC v8Stage IVA Laryngeal Cancer AJCC v8Stage IVA Lip and Oral Cavity Cancer AJCC v8Stage IVA Oropharyngeal (p16-Negative) Carcinoma AJCC v8Stage IVB Hypopharyngeal Carcinoma AJCC v8Stage IVB Laryngeal Cancer AJCC v8Stage IVB Lip and Oral Cavity Cancer AJCC v8Stage IVB Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions
PROCEDURE

Computed Tomography

Undergo CT or PET/CT

OTHER

Fludeoxyglucose F-18

Given IV

RADIATION

Intensity-Modulated Radiation Therapy

Undergo IMRT

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Peposertib

Given PO

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

Trial Locations (27)

10016

Laura and Isaac Perlmutter Cancer Center at NYU Langone, New York

11501

NYU Langone Hospital - Long Island, Mineola

14620

Highland Hospital, Rochester

14642

University of Rochester, Rochester

22031

Inova Schar Cancer Institute, Fairfax

29425

Medical University of South Carolina, Charleston

30308

Emory University Hospital Midtown, Atlanta

30322

Emory University Hospital/Winship Cancer Institute, Atlanta

33136

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33612

Moffitt Cancer Center, Tampa

40202

The James Graham Brown Cancer Center at University of Louisville, Louisville

43210

Ohio State University Comprehensive Cancer Center, Columbus

57104

Sanford Cancer Center Oncology Clinic, Sioux Falls

61801

Carle Cancer Center, Urbana

61832

Carle at The Riverfront, Danville

61938

Carle Physician Group-Mattoon/Charleston, Mattoon

62401

Carle Physician Group-Effingham, Effingham

73104

University of Oklahoma Health Sciences Center, Oklahoma City

77030

M D Anderson Cancer Center, Houston

85054

Mayo Clinic Hospital in Arizona, Phoenix

85234

Banner MD Anderson Cancer Center, Gilbert

85719

Banner University Medical Center - Tucson, Tucson

University of Arizona Cancer Center-North Campus, Tucson

92093

UC San Diego Moores Cancer Center, La Jolla

94304

Stanford Cancer Institute Palo Alto, Palo Alto

97213

Providence Portland Medical Center, Portland

57117-5134

Sanford USD Medical Center - Sioux Falls, Sioux Falls

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

NRG Oncology

OTHER

lead

National Cancer Institute (NCI)

NIH