Nimotuzumab in Combined With Chemoradiotherapy to Treat the Newly Diagnosed Diffuse Intrinsic Pontine Glioma in Children

PHASE3UnknownINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

April 3, 2021

Primary Completion Date

October 8, 2023

Study Completion Date

December 8, 2023

Conditions
Diffuse Intrinsic Pontine Glioma
Interventions
DRUG

Nimotuzumab+CRT(concurrent IMRT and TMZ)

"Drug: Nimotuzumab Concurrent radiochemotherapy period, 150mg/m2, weekly, for 6 weeks; Maintenance period, from the 7th to the 52nd week, 150mg/m2, every two weeks until disease progression or intolerable toxicity.~Other Names: h-R3~Drug: Temozolomide Concurrent radiochemotherapy period, 75mg/m2, daily, for 6 weeks; Maintenance period, rest from the 7th to 10th weeks, from the 11th week, 150-200mg/m2, day1 to day5, 21 days for a cycle, for 6 cycles.~Other Names: TMZ"

Trial Locations (8)

Unknown

RECRUITING

The Third People's Hospital of Zhengzhou, Zhengzhou

NOT_YET_RECRUITING

Xiangya Hospital of Centre-south University, Changsha

NOT_YET_RECRUITING

West China Hospital, Sichuan University, Chengdu

RECRUITING

Beijing Tiantan Hospital, Capital Medical University, Beijing

NOT_YET_RECRUITING

Peking Union Medical College Hospital, Beijing

RECRUITING

Xuanwu Hospital Capital Medical University, Beijing

NOT_YET_RECRUITING

Shandong Cancer Hospital, Jinan

RECRUITING

Xinhua Hospital Affiliated To Shanghai Jiao Tong University School Of Medicine, Shanghai

All Listed Sponsors
lead

Biotech Pharmaceutical Co., Ltd.

OTHER