NCT04528680 - Ultrasound-based Blood-brain Barrier Opening and Albumin-bound Paclitaxel and Carboplatin for Recurrent Glioblastoma | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

October 29, 2020

Primary Completion Date

November 30, 2025

Study Completion Date

November 30, 2025

Conditions

GlioblastomaGliosarcomaGBMGlioblastoma MultiformeGlioblastoma, IDH-wildtypeRecurrent Glioblastoma

Interventions

DEVICE

Sonication for opening of blood-brain barrier

Implantation of SC-9 device and repeat activation of 9 ultrasound emitters during i.v. injection of microbubbles

DRUG

Chemotherapy, albumin-bound paclitaxel

Intravenous infusion of ABX over 30 minutes

DRUG

Chemotherapy, carboplatin

Intravenous infusion of carboplatin over 30 minutes

Trial Locations (1)

Northwestern Memorial Hospital, Chicago