REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

490

Participants

Timeline

Start Date

September 2, 2020

Primary Completion Date

September 27, 2025

Study Completion Date

December 31, 2027

Conditions
FGFR2 AmplificationFGFR2 Gene MutationFGFR2 Gene Fusion/RearrangementFGFR2 Gene TranslocationFGFR2 Gene ActivationIntrahepatic CholangiocarcinomaCholangiocarcinomaOther Solid Tumors, Adult
Interventions
DRUG

RLY-4008

RLY-4008 is an oral inhibitor of FGFR2

Trial Locations (48)

2010

St. Vincent's Hosptial Sydney, Darlinghurst

4101

Icon Cancer Care South Brisbane, South Brisbane

6009

Linear Clinical Research Ltd, Nedlands

10065

Memorial Sloan Kettering Cancer Center, New York

17176

Karolinska University Hospital, Stockholm

19111

Fox Chase Cancer Center, Philadelphia

20141

Istituto Europeo di Oncologia, Milan

21079

Centre Georges François Leclerc, Dijon

28040

Hospital Universitario Fundación Jiménez Díaz- START MADRID, Madrid

28050

Hospital Universitario HM Sanchinarro-START MADRID-CIOCC, Madrid

30322

Winship Cancer Institute, Emory University, Atlanta

30625

Medizinische Hochschule Hannover, Hanover

31008

Clinica de Universidad de Navarra, Pamplona

32224

Mayo Clinic, Jacksonville

33076

Institut Bergonie, Bordeaux

33612

Moffitt Cancer Center, Tampa

35294

The University of Alabama at Birmingham, Birmingham

40447

China Medical University Hospital, Taichung

44195

Taussig Cancer Institute Cleveland Clinic, Cleveland

46010

Hospital Clínico Universitario de Valencia, Valencia

48109

University of Michigan, Ann Arbor

55905

Mayo Clinic, Rochester

60637

University of Chicago Medical Center, Chicago

69120

Universitätsklinikum Heidelberg, Heidelberg

69373

Centre Leon Berard, Lyon

75246

Texas Oncology, Dallas

77030

The University of Texas M.D. Anderson Cancer Center, Houston

81377

LMU Klinikum, Campus Grosshadern, Munich

84112

Huntsman Cancer Institute, University of Utah, Salt Lake City

85054

Mayo Clinic, Phoenix

90033

USC Norris Comprehensive Cancer Center, Los Angeles

94158

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

94805

Gustave Roussy Cancer Campus, Paris

98101

Virginia Mason Medical Center, Seattle

169610

National Cancer Center Singapore, Singapore

999077

Queen Mary Hospital, Hong Kong

02114

Massachusetts General Hospital, Boston

1066 CX

Netherlands Cancer institute, Amsterdam

3015 GD

Erasmus MC, Rotterdam

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

08023

START Barcelona-Hospital HM Nou Delfos, Barcelona

08035

Hospital Universitari Vall d'Hebron, Barcelona

SE1 9RT

Guy's Hospital, London

W1G 6AD

Sarah Cannon Research Institute UK, London

W1T 7HA

University College London Hospitals NHS Foundation Trust, London

M20 4BX

The Christie NHS Foundation Trust, Manchester

Sponsors
All Listed Sponsors
lead

Elevar Therapeutics

INDUSTRY

NCT04526106 - REFOCUS: A First-in-Human Study of Highly Selective FGFR2 Inhibitor, RLY-4008, in Patients With ICC and Other Advanced Solid Tumors | Biotech Hunter | Biotech Hunter