REtreatment With VEnetoclax and Acalabrutinib After Venetoclax Limited Duration (REVEAL)

PHASE2RecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

December 23, 2020

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2032

Conditions
CLL/SLL
Interventions
DRUG

Venetoclax/Acalabrutinib

All patients will receive a lead-in with 2 cycles of acalabrutinib 100 mg bid. Hereafter patients will continue with ramp-up of venetoclax followed by daily 400 mg venetoclax in combination with acalabrutinib for 24 cycles. Patients will be treated until they have received a total of 26 cycles or until progression, whichever comes first.

Trial Locations (18)

Unknown

NOT_YET_RECRUITING

BE-Bruxelles-STLUC, Brussels

NOT_YET_RECRUITING

BE-Leuven-UZLEUVEN, Leuven

NOT_YET_RECRUITING

DK-Aarhus N-AUH, Aarhus

RECRUITING

NL-Den Bosch-JBZ, 's-Hertogenbosch

RECRUITING

NL-Amsterdam-AMC, Amsterdam

RECRUITING

NL-Arnhem-RIJNSTATE, Arnhem

RECRUITING

NL-Breda-AMPHIA, Breda

RECRUITING

NL-Delft-RDGG, Delft

NOT_YET_RECRUITING

NL-Dordrecht-ASZ, Dordrecht

RECRUITING

NL-Ede-ZGV, Ede

RECRUITING

NL-Eindhoven-MAXIMAMC, Eindhoven

RECRUITING

NL-Groningen-UMCG, Groningen

RECRUITING

NL-Leeuwarden-MCL, Leeuwarden

RECRUITING

NL-Maastricht-MUMC, Maastricht

RECRUITING

NL-Nieuwegein-ANTONIUS, Nieuwegein

RECRUITING

NL-Rotterdam-IKAZIA, Rotterdam

RECRUITING

NL-Rotterdam-MAASSTADZIEKENHUIS, Rotterdam

NOT_YET_RECRUITING

NL-Utrecht-UMCUTRECHT, Utrecht

All Listed Sponsors
lead

Stichting Hemato-Oncologie voor Volwassenen Nederland

OTHER