Treatment of Adynamic Bone Disorder With Parathyroid Hormone in Chronic Kidney Disease

PHASE4RecruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 15, 2021

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2027

Conditions
Adynamic Bone DiseaseChronic Kidney DiseasesCardiac DiseaseChronic Kidney Disease-Mineral and Bone Disorder
Interventions
DRUG

Teriparatide

20 micrograms

DIAGNOSTIC_TEST

DXA,VFA, X-ray, HR-pQCT, 18-F NAF PET/CT

All participants undergo DXA and VFA or X-ray scans 3 times during the study. Some participants (those connected to Herlev) are offered 18F NAF PET/CT scans at baseline and after 12 months and some participants (those connected to Odense University Hospital and Aalborg University Hospital) are offered HR-pQCT scans at baseline and after 12 months. The 18F-NAF PET/CT and HR-pQCT are optional, so it is not a must to have these procedures done to participate in the study.

PROCEDURE

Bone biopsy

All participants are invited to undergo a bone biopsy after 12 months, but it is not a must to have the procedure done to participate in the study.

DIAGNOSTIC_TEST

Cardiac tests

All participants are invited to undergo 24-hour blood pressure measurements and pulse wave measurements at baseline and after 18 months, but it is not a must to have these procedures done to participate in the study.

OTHER

Blood and urine samples and physical examination

All participants must undergo a physical examination and deliver blood and urine samples in order to participate in the study.

Trial Locations (4)

2730

RECRUITING

Herlev and Gentofte Hospital, Herlev Hospital, Herlev

2820

NOT_YET_RECRUITING

Steno Diabetes Center Copenhagen, Gentofte Municipality

5000

NOT_YET_RECRUITING

Odense University Hospital, Odense

9000

NOT_YET_RECRUITING

Aalborg University Hospital, Aalborg

All Listed Sponsors
collaborator

Odense University Hospital

OTHER

collaborator

Steno Diabetes Center Copenhagen

OTHER

collaborator

Rigshospitalet, Denmark

OTHER

collaborator

Aalborg University Hospital

OTHER

lead

Ditte Hansen

OTHER