Safety and Efficacy Study of CFI-402411 in Subjects With Advanced Solid Malignancies

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

August 31, 2020

Primary Completion Date

November 30, 2025

Study Completion Date

December 31, 2025

Conditions
Advanced Solid Malignancies
Interventions
DRUG

CFI-402411

CFI-402411 is administered orally once daily. The starting dose is 80 mg/day for escalation arms and the recommended dose for the expansion arms.

DRUG

Pembrolizumab

Pembrolizumab will be given at its labeled dose and schedule, 200 mg administered as an intravenous infusion over 30 minutes every 3 weeks.

Trial Locations (13)

22031

Virginia Cancer Specialist, Fairfax

34232

Florida Cancer Specialists, Sarasota

37023

SCRI - Nashville, Nashville

49546

START - Mid-West, Grand Rapids

77030

MD Anderson, Houston

78229

START - San Antonio, San Antonio

90025

The Angeles Clinic, Los Angeles

92093

University of California San Diego, La Jolla

06519

Yale Cancer Center, New Haven

T6G1Z2

Cross Cancer Institute, Edmonton

K1H8L6

The Ottawa Hospital, Ottawa

M5G2M9

Princess Margaret Cancer Centre, Toronto

Unknown

Prince of Wales Hospital, Shatin

All Listed Sponsors
collaborator

TIO Discovery Engine

UNKNOWN

lead

Treadwell Therapeutics, Inc

INDUSTRY