Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

December 1, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2025

Conditions
Colorectal CancerVitamin CGLUT3
Interventions
DRUG

Ascorbic acid

1.5g/kg/day, D1-3, every 2 weeks

DRUG

FOLFOX Protocol

Oxaliplatin 130 mg/m² d1 concurrent with Leucovorin 400 mg/m², followed by Oxaliplatin 85 mg/m² d1 followed by Bolus 5FU 400 mg/m² , followed by Infusional 5FU 2400 mg/m² over 46 hours, every 2 weeks with or without bevacizumab 5mg/kg, every 2 weeks

DRUG

Adebrelimab

20mg/Kg intravenously every 3 weeks

Trial Locations (1)

200032

RECRUITING

Fudan university shanghai cancer center, Shanhai

All Listed Sponsors
lead

Fudan University

OTHER