NCT04514497View on ClinicalTrials.gov

Testing the Addition of an Anti-cancer Drug, BAY 1895344, to Usual Chemotherapy for Advanced Stage Solid Tumors, With a Specific Focus on Patients With Small Cell Lung Cancer, Poorly Differentiated Neuroendocrine Cancer, and Pancreatic Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

28

Participants

Timeline

Start Date

October 20, 2021

Primary Completion Date

February 15, 2025

Study Completion Date

March 4, 2026

Conditions
Metastatic Lung Small Cell CarcinomaMetastatic Malignant Solid NeoplasmMetastatic Neuroendocrine CarcinomaMetastatic Pancreatic AdenocarcinomaStage III Lung Cancer AJCC v8Stage III Pancreatic Cancer AJCC v8Stage IV Lung Cancer AJCC v8Stage IV Pancreatic Cancer AJCC v8Unresectable Lung Small Cell CarcinomaUnresectable Malignant Solid NeoplasmUnresectable Neuroendocrine CarcinomaUnresectable Pancreatic Adenocarcinoma
Interventions
PROCEDURE

Biopsy

Undergo tumor biopsy

PROCEDURE

Biospecimen Collection

Undergo collection of blood samples

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Elimusertib

Given PO

DRUG

Irinotecan Hydrochloride

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

DRUG

Topotecan Hydrochloride

Given IV

Trial Locations (23)

10461

Montefiore Medical Center-Einstein Campus, The Bronx

15232

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

37232

Vanderbilt University/Ingram Cancer Center, Nashville

55905

Mayo Clinic in Rochester, Rochester

63110

Washington University School of Medicine, St Louis

63129

Siteman Cancer Center-South County, St Louis

63136

Siteman Cancer Center at Christian Hospital, St Louis

63141

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

64064

University of Kansas Cancer Center - Lee's Summit, Lee's Summit

64116

University of Kansas Cancer Center at North Kansas City Hospital, North Kansas City

64154

University of Kansas Cancer Center - North, Kansas City

66160

University of Kansas Cancer Center, Kansas City

66205

University of Kansas Clinical Research Center, Fairway

University of Kansas Hospital-Westwood Cancer Center, Westwood

66210

University of Kansas Cancer Center-Overland Park, Overland Park

66211

University of Kansas Hospital-Indian Creek Campus, Overland Park

73104

University of Oklahoma Health Sciences Center, Oklahoma City

85054

Mayo Clinic Hospital in Arizona, Phoenix

92868

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

06520

Yale University, New Haven

06611

Smilow Cancer Hospital Care Center-Trumbull, Trumbull

32224-9980

Mayo Clinic in Florida, Jacksonville

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH