A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIa AL Amyloidosis (CARES)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

281

Participants

Timeline

Start Date

November 3, 2020

Primary Completion Date

April 8, 2025

Study Completion Date

April 8, 2027

Conditions
AL Amyloidosis
Interventions
DRUG

CAEL-101

The investigational product, CAEL-101, is formulated as a sterile liquid solution of protein plus excipients for dilution in a single-use, stoppered, glass vial. Each 10 mL vial contains 300 mg of CAEL-101 at a concentration of 30 mg/mL. CAEL-101 will be diluted with commercially available 0.9% Normal Saline.

OTHER

Placebo

Commercially available 0.9% Normal Saline will be used as the placebo.

DRUG

cyclophosphamide, bortezomib, and dexamethasone (CyBorD) regimen

According to institutional standard of care.

Trial Locations (110)

1070

Research Site, Anderlecht

1090

Research Site, Vienna

2145

Research Site, Westmead

3000

Research Site, Leuven

3128

Research Site, Box Hill

4020

Research Site, Linz

4102

Research Site, Woolloongabba

8035

Research Site, Barcelona

10032

Research Site, New York

10065

Research Site, New York

11528

Research Site, Athens

12203

Research Site, Berlin

12808

Research Site, Prague

13009

Research Site, Marseille

14033

Research Site, Caen

14642

Research Site, Rochester

18014

Research Site, Granada

19104

Research Site, Philadelphia

21079

Research Site, Dijon

21201

Research Site, Baltimore

22767

Research Site, Hamburg

25123

Research Site, Brescia

26504

Research Site, Rio

27157

Research Site, Winston-Salem

27599

Research Site, Chapel Hill

27705

Research Site, Durham

28003

Research Site, Madrid

28040

Research Site, Madrid

28222

Research Site, Majadahonda

31008

Research Site, Pamplona

31096

Research Site, Haifa

31100

Research Site, Toulouse

32224

Research Site, Jacksonville

33331

Research Site, Weston

33394

Research Site, Gijón

33604

Research Site, Pessac

35033

Research Site, Rennes

37007

Research Site, Salamanca

37044

Research Site, Tours

37232

Research Site, Nashville

40225

Research Site, Düsseldorf

41013

Research Site, Seville

43210

Research Site, Columbus

44195

Research Site, Cleveland

45147

Research Site, Essen

46009

Research Site, Valencia

46202

Research Site, Indianapolis

48201

Research Site, Detroit

49100

Research Site, Petah Tikva

52621

Research Site, Tel Litwinsky

53226

Research Site, Milwaukee

53792

Research Site, Madison

54636

Research Site, Thessaloniki

55905

Research Site, Rochester

59037

Research Site, Lille

63110

Research Site, St Louis

64239

Research Site, Tel Aviv

69120

Research Site, Heidelberg

69310

Research Site, Pierre-Bénite

70112

Research Site, New Orleans

75010

Research Site, Paris

75390

Research Site, Dallas

77030

Research Site, Houston

84112

Research Site, Salt Lake City

85259

Research Site, Scottsdale

86021

Research Site, Poitiers

87042

Research Site, Limoges

91010

Research Site, Duarte

91120

Research Site, Jerusalem

94000

Research Site, Créteil

94143

Research Site, San Francisco

94304

Research Site, Palo Alto

97080

Research Site, Würzburg

97239

Research Site, Portland

98109

Research Site, Seattle

100034

Research Site, Beijing

100730

Research Site, Beijing

197022

Research Site, Saint Petersburg

200032

Research Site, Shanghai

215006

Research Site, Suzhou

310009

Research Site, Hangzhou

325000

Research Site, Wenzhou

430022

Research Site, Wuhan

510180

Research Site, Guangzhou

02111

Research Site, Boston

02118

Research Site, Boston

02215

Research Site, Boston

WA6150

Research Site, Murdoch

90110-270

Research Site, Porto Alegre

14051-140

Research Site, Ribeirão Preto

41253-190

Research Site, Salvador

T2N 4N2

Research Site, Calgary

M5G 2M9

Research Site, Toronto

708 52

Research Site, Ostrava Poruba

960-1295

Research Site, Fukushima

920-8641

Research Site, Kanazawa

277-8567

Research Site, Kashiwa-shi

603-8151

Research Site, Kita-ku

860-8556

Research Site, Kumamoto

390-8621

Research Site, Matsumoto-shi

467-8602

Research Site, Nagoya

150-8935

Research Site, Shibuya-ku

80-214

Research Site, Gdansk

01-748

Research Site, Warsaw

03722

Research Site, Seoul

06351

Research Site, Seoul

06591

Research Site, Seoul

08036

Research Site, Barcelona

G12 0YN

Research Site, Glasgow

NW1 2PG

Research Site, London

Sponsors
All Listed Sponsors
lead

Alexion Pharmaceuticals, Inc.

INDUSTRY