A Study to Evaluate the Efficacy and Safety of CAEL-101 in Patients With Mayo Stage IIIb AL Amyloidosis (CARES)

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

125

Participants

Timeline

Start Date

August 25, 2020

Primary Completion Date

May 10, 2025

Study Completion Date

October 22, 2027

Conditions
AL Amyloidosis
Interventions
DRUG

CAEL-101

The investigational product, CAEL-101, is formulated as a sterile liquid solution of protein plus excipients for dilution in a single-use, stoppered, glass vial. Each 10 mL vial contains 300 mg of CAEL-101 at a concentration of 30 mg/mL. CAEL-101 will be diluted with commercially available 0.9% Normal Saline.

OTHER

Placebo

Commercially available 0.9% Normal Saline will be used as the placebo.

DRUG

cyclophosphamide, bortezomib, and Dexamethasone (CyBorD) regimen

According to institutional standard of care.

Trial Locations (90)

1070

Research Site, Anderlecht

1090

Research Site, Vienna

2145

Research Site, Westmead

3000

Research Site, Leuven

3128

Research Site, Box Hill

4020

Research Site, Linz

4102

Research Site, Brisbane

8035

Research Site, Barcelona

10032

Research Site, New York

10065

Research Site, New York

11528

Research Site, Athens

12808

Research Site, Prague

13009

Research Site, Marseille

13353

Research Site, Berlin

14033

Research Site, Caen

14642

Research Site, Rochester

19104

Research Site, Philadelphia

22767

Research Site, Hamburg

26504

Research Site, Rio

27100

Research Site, Pavia

27157

Research Site, Winston-Salem

28222

Research Site, Majadahonda

31008

Research Site, Pamplona

31096

Research Site, Haifa

31100

Research Site, Toulouse

33331

Research Site, Weston

33394

Research Site, Gijón

33604

Research Site, Pessac

35033

Research Site, Rennes

37044

Research Site, Tours

37232

Research Site, Nashville

40225

Research Site, Düsseldorf

41013

Research Site, Seville

43210

Research Site, Columbus

44195

Research Site, Cleveland

45147

Research Site, Essen

46202

Research Site, Indianapolis

48201

Research Site, Detroit

52621

Research Site, Tel Litwinsky

53226

Research Site, Milwaukee

55905

Research Site, Rochester

56126

Research Site, Pisa

63110

Research Site, St Louis

69120

Research Site, Heidelberg

69310

Research Site, Pierre-Bénite

70112

Research Site, New Orleans

70852

Research Site, Ostrava - Poruba

75010

Research Site, Paris

75390

Research Site, Dallas

77030

Research Site, Houston

80131

Research Site, Napoli

84112

Research Site, Salt Lake City

86021

Research Site, Poitiers

87042

Research Site, Limoges

91010

Research Site, Duarte

91120

Research Site, Jerusalem

94000

Research Site, Créteil

94143

Research Site, San Francisco

94304

Research Site, Palo Alto

97080

Research Site, Würzburg

97239

Research Site, Portland

98109

Research Site, Seattle

100730

Research Site, Beijing

310009

Research Site, Hangzhou

325000

Research Site, Wenzhou

430022

Research Site, Wuhan

510180

Research Site, Guangzhou

02111

Research Site, Boston

02118

Research Site, Boston

02215

Research Site, Boston

90110-270

Research Site, Porto Alegre

14048-900

Research Site, Ribeirão Preto

41253-190

Research Site, Salvador

15090-000

Research Site, São José do Rio Preto

T2N 4N2

Research Site, Calgary

T6G 1Z2

Research Site, Edmonton

M5G 2M9

Research Site, Toronto

00128

Research Site, Roma

960-1295

Research Site, Fukushima

467-8602

Research Site, Nagoya

150-8935

Research Site, Shibuya-ku

9713 GZ

Research Site, Groningen

3508 GA

Research Site, Utrecht

80-214

Research Site, Gdansk

60-569

Research Site, Poznan

01-748

Research Site, Warsaw

03080

Research Site, Seoul

06351

Research Site, Seoul

08036

Research Site, Barcelona

WC1E 6AG

Research Site, London

Sponsors
All Listed Sponsors
lead

Alexion Pharmaceuticals, Inc.

INDUSTRY