A Study of GMA301 in Subjects With Pulmonary Arterial Hypertension

PHASE1UnknownINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

October 22, 2020

Primary Completion Date

October 26, 2022

Study Completion Date

June 10, 2023

Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG

Q4W GMA301 IV injections (300 mg)

Each cohort will contain 12 subjects, 9 of whom will be administered active GMA301 and 3 of whom will be administrated placebo.

DRUG

Q4W GMA301 IV injections (600 mg)

Each cohort will contain 12 subjects, 9 of whom will be administered active GMA301 and 3 of whom will be administrated placebo.

DRUG

Q4W GMA301 IV injections (1000 mg)

Each cohort will contain 12 subjects, 9 of whom will be administered active GMA301 and 3 of whom will be administrated placebo.

DRUG

Q4W GMA301 IV injections (1800 mg)

Each cohort will contain 12 subjects, 9 of whom will be administered active GMA301 and 3 of whom will be administrated placebo.

OTHER

Q4W placebo IV injections

Placebo is indistinguishable from GMA301.

Trial Locations (7)

02115

RECRUITING

Brigham and Women's Hospital, Boston

Unknown

RECRUITING

Peking Union Medical College Hospital - Dongcheng District, Beijing

RECRUITING

Xiangya Hospital, Central South University, Changsha

RECRUITING

The First Affiliated Hospital of Chongqing Medical University, Chongqing

RECRUITING

Guangdong General Hospital, Guangzhou

RECRUITING

Shanghai Pulmonary Hospital, Shanghai

RECRUITING

The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Gmax Biopharm LLC.

INDUSTRY