Use of Phenylephrine for Assessment of Mitral Regurgitation Severity

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

December 1, 2020

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Mitral Regurgitation
Interventions
DRUG

Mydfrin

A test dose of 20 mcg of Mydfrin will be administered through the peripheral intravenous line. BP will be monitored after each bolus of phenylephrine. Subsequent Mydfrin injections will then be administered in 50 mcg aliquots every 10-15 minutes, instead of 40 mcg, until the mean arterial blood pressure (MAP) increases by ≥ 20 mm Hg from the baseline MAP, however making sure not to exceed a MAP of 100 mmHg. Once a desired blood pressure has been achieved and maintained, echocardiographic evaluation of mitral regurgitation would be performed.

Trial Locations (1)

10470

RECRUITING

Montefiore Medical Center, New York

All Listed Sponsors
collaborator

Baylor College of Medicine

OTHER

lead

Montefiore Medical Center

OTHER