CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

October 13, 2020

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2026

Conditions
Non Small Cell Lung Cancer
Interventions
BIOLOGICAL

Aglatimagene besadenovec

Two courses (Cohort 1A and Cohort 2A) or three courses (Cohort 1B and Cohort 2B) of CAN-2409 injection into an accessible involved tumor site followed by 14 days of prodrug (valacyclovir or acyclovir). For Cohort 1B, the third course is optional. All patients will continue standard of care immune checkpoint inhibitor with or without chemotherapy.

Trial Locations (14)

10016

NYU Langone Health, New York

19104

University of Pennsylvania, Philadelphia

21201

University of Maryland, Baltimore, Baltimore

23249

Hunter Holmes McGuire VA Medical Center, Richmond

23298

Virginia Commonwealth University, Richmond

37232

Vanderbilt University Medical Center, Nashville

43210

The Ohio State University Wexner Medical Center, Columbus

55905

Mayo Clinic, Rochester

60637

University of Chicago, Chicago

77030

The University of Texas MD Anderson Cancer Center, Houston

84112

University of Utah, Salt Lake City

85054

Mayo Clinic Hospital, Phoenix

06030

UConn Health, Farmington

06510

Yale University, Yale Cancer Center, New Haven

Sponsors
All Listed Sponsors
collaborator

NYU Langone Health

OTHER

lead

Candel Therapeutics, Inc.

INDUSTRY

NCT04495153 - CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLC | Biotech Hunter | Biotech Hunter