Drug-drug Interaction Study of Gepotidacin

Gepotidacin tablets will be available as unit dose strength 750 mg and will be administered orally.

Cimetidine tablets will be available as unit dose strength 400 mg and will be administered orally.

Rifampicin Capsules will be available as unit dose strength 300 mg and will be administered orally.

Midazolam oral syrup 2 milligrams per milliliter (mg/mL) will be available to be administered orally.

Digoxin tablets will be available as unit dose strength 0.25 mg and will be administered orally.

Placebo matching to gepotidacin tablets will be administered orally.