Autologous Stem Cell Transplant Followed by Polatuzumab Vedotin in Patients With B-cell Non-Hodgkin and Hodgkin Lymphoma

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

August 1, 2021

Primary Completion Date

August 15, 2024

Study Completion Date

August 15, 2025

Conditions
B-cell LymphomaBurkitt LymphomaDiffuse Large B Cell LymphomaFollicular LymphomaMantle Cell LymphomaMarginal Zone LymphomaTransformed Non-Hodgkin LymphomaRichter SyndromeHodgkin Lymphoma
Interventions
DRUG

Polatuzumab vedotin

All patients will receive a myeloablative conditioning regimens (BEAM or CBV, as selected by the treating physician) followed by autologous stem cell transplant (ASCT). All patients on this study will receive an autologous stem cell transplant (ASCT) on Day 0 followed by supportive care including the drugs sargarmostim and filgrastim until blood counts are stable. If a complete, partial, or stable response is achieved following ASCT, the patient will receive an IV dose of Polatuzumab Vedotin once every 21 days until he/she receives 8 doses.

Trial Locations (1)

10595

RECRUITING

New York Medical Center, Valhalla

Sponsors
All Listed Sponsors
lead

New York Medical College

OTHER