A Study to Evaluate Effects of Proton-pump Inhibitor on Acalabrutinib Capsule When Administered Orally With COCA-COLA in Healthy Participants

PHASE1CompletedINTERVENTIONAL
Enrollment

35

Participants

Timeline

Start Date

July 20, 2020

Primary Completion Date

August 28, 2020

Study Completion Date

August 28, 2020

Conditions
Infectious Disease
Interventions
DRUG

Acalabrutinib

Participants will receive single oral dose of acalabrutinib on day 1 as per the arms they are randomized.

DRUG

Rabeprazole

Participants will receive twice daily oral dose of 20 mg rabeprazole on days -3, -2, and -1.

Trial Locations (1)

92801

Research Site, Anaheim

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Acerta Pharma BV

INDUSTRY

lead

AstraZeneca

INDUSTRY