Neurobiological Mechanisms of Stress in Youth With Chronic Widespread Pain

NARecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

November 4, 2021

Primary Completion Date

August 31, 2024

Study Completion Date

August 31, 2024

Conditions
Chronic Widespread PainStress, PsychologicalStress, Physiological
Interventions
DIAGNOSTIC_TEST

functional Magnetic Resonance Imaging (fMRI)

Participants will undergo a one hour fMRI scan with pain-induction using heat-based QST protocol.

OTHER

Allostatic Load Composite

All participants will be asked to provide saliva samples to measure cortisol response over time and dehydroepiandrosterone (DHEA) in addition to physiological measurements such as blood pressure/pulse, height/weight, and waist-hip ratio. Measurements will be taken at baseline and 4-month follow-up.

Trial Locations (1)

02115

RECRUITING

Boston Children's Hospital, Boston

All Listed Sponsors
collaborator

National Center for Complementary and Integrative Health (NCCIH)

NIH

lead

Boston Children's Hospital

OTHER