Combination of Atezolizumab With Dendritic Cell Vaccine in Patients With Lung Cancer

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

March 17, 2021

Primary Completion Date

August 31, 2024

Study Completion Date

October 31, 2024

Conditions
Extensive-stage Small Cell Lung Cancer
Interventions
DRUG

Atezolizumab 1200 mg in 20 ML Injection

"\- Induction (4 cycles, every 3 weeks): Atezolizumab, 1200 mg administered intravenously every 3 weeks on day 1 of each cycle)~\- Maintenance (only patients without PD after 4 induction cycles, up to PD): Atezolizumab iv (1200 mg/IV on day 1 every 3 weeks)"

BIOLOGICAL

ADC Vaccine

\- Maintenance (only patients without PD after 4 induction cycles, up to PD): DCV intradermally (max. 6 doses) on weeks 1, 3, 6, 9, 21, 33.

DRUG

Carboplatin

\- Induction (4 cycles, every 3 weeks): Carboplatin AUC 5 (5 mg per milliliter per minute, administered intravenously on day 1 of each cycle) and etoposide (100 mg per square meter of body-surface area, administered intravenously on days 1 through 3 of each cycle)

Trial Locations (3)

08916

ICO Badalona, Badalona

08028

Quirón Dexeus, Barcelona

08036

Hospital Clínic Barcelona, Barcelona

All Listed Sponsors
collaborator

Roche Pharma AG

INDUSTRY

collaborator

Fundacion Clinic per a la Recerca Biomédica

OTHER

lead

Instituto Oncológico Dr Rosell

OTHER