A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

148

Participants

Timeline

Start Date

October 20, 2021

Primary Completion Date

October 1, 2026

Study Completion Date

October 31, 2027

Conditions
Endometrial Cancer
Interventions
DRUG

Atezolizumab - 28 Day Cycle

Atezolizumab will be given to participants intravenously at a dosage of 1680 mg on day 1 of each 28-day cycle.

DRUG

Bevacizumab

Bevacizumab will be given to participants intravenously at a dosage of 10mg per participant kilogram every 2 weeks of the 28-day cycle.

DRUG

Ipatasertib

Ipatasertib will be given as an orally at a dosage of 400 mg once daily for 21 days of each 28-day cycle.

DRUG

Talazoparib

Talazoparib will be given in an orally at a dosage of 1 mg once daily for each day of the 28-day cycle.

DRUG

Trastuzumab emtansine

Trastuzumab emtansine be given to participants intravenously at a dosage of 3.6 mg per participant kilogram, on day 1 of each 21-day cycle.

DRUG

Tiragolumab

Tiragolumab will be given to participants intravenously at a dosage of 840 mg on day 1 of each 28-day cycle.

DRUG

Atezolizumab - 21 Day Cycle

Atezolizumab will be given to participants intravenously at a dosage of 1200 mg on day 1 of each 21-day cycle.

DRUG

Inavolisib

Inavolisib will be given in an orally at a dosage of 9 mg once daily for each day of the 28-day cycle.

DRUG

Letrozole

Letrozole will be given orally at a dosage of 2.5 mg once daily for each day of the 28-day cycle.

DRUG

Giredestrant

Giredestrant will be given orally at a dosage of 30 mg once daily for each day of the 28-day cycle.

DRUG

Abemaciclib

Giredestrant will be given orally at a dosage of 150 mg twice daily for each day of the 28-day cycle.

Trial Locations (21)

10065

RECRUITING

Weill Cornell Medicine, New York

14263

ACTIVE_NOT_RECRUITING

Roswell Park, Buffalo

15261

ACTIVE_NOT_RECRUITING

University of Pittsburgh Medical Center, Pittsburgh

20007

RECRUITING

Medstar Georgetown Cancer Institute, Washington D.C.

27710

RECRUITING

Duke University Cancer Center, Durham

33140

RECRUITING

Mount Sinai Comprehensive Cancer Center, Miami Beach

38120

WITHDRAWN

Baptist Memorial Hospital, Memphis

55455

RECRUITING

University of Minnesota, Minneapolis

60637

RECRUITING

University of Chicago, Chicago

63110

WITHDRAWN

Washington University School of Medicine Siteman Cancer Center, St Louis

66205

RECRUITING

University of Kansas Cancer Center, Westwood

68114

RECRUITING

Nebraska Methodist Hospital, Omaha

73104

RECRUITING

University of Oklahoma Health Stephenson Cancer Center, Oklahoma City

91010

ACTIVE_NOT_RECRUITING

City of Hope Comprehensive Cancer Center, Duarte

94143

RECRUITING

UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco

97213

RECRUITING

Providence Portland Cancer Institute, Portland

04074

RECRUITING

Maine Medical Center, Scarborough

02125

RECRUITING

Dana Farber Cancer Institute, Boston

07631

ACTIVE_NOT_RECRUITING

Englewood Health, Englewood

07960

RECRUITING

Atlantic Health Systems/Morristown Medical Center, Morristown

02903

RECRUITING

Lifespan - Rhode Island Hospital, Providence

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

collaborator

Foundation Medicine

INDUSTRY

collaborator

Pfizer

INDUSTRY

collaborator

Eli Lilly and Company

INDUSTRY

lead

Alliance Foundation Trials, LLC.

OTHER

NCT04486352 - A Study of Targeted Agents for Patients With Recurrent or Persistent Endometrial Cancer | Biotech Hunter | Biotech Hunter