148
Participants
Start Date
October 20, 2021
Primary Completion Date
October 1, 2026
Study Completion Date
October 31, 2027
Atezolizumab - 28 Day Cycle
Atezolizumab will be given to participants intravenously at a dosage of 1680 mg on day 1 of each 28-day cycle.
Bevacizumab
Bevacizumab will be given to participants intravenously at a dosage of 10mg per participant kilogram every 2 weeks of the 28-day cycle.
Ipatasertib
Ipatasertib will be given as an orally at a dosage of 400 mg once daily for 21 days of each 28-day cycle.
Talazoparib
Talazoparib will be given in an orally at a dosage of 1 mg once daily for each day of the 28-day cycle.
Trastuzumab emtansine
Trastuzumab emtansine be given to participants intravenously at a dosage of 3.6 mg per participant kilogram, on day 1 of each 21-day cycle.
Tiragolumab
Tiragolumab will be given to participants intravenously at a dosage of 840 mg on day 1 of each 28-day cycle.
Atezolizumab - 21 Day Cycle
Atezolizumab will be given to participants intravenously at a dosage of 1200 mg on day 1 of each 21-day cycle.
Inavolisib
Inavolisib will be given in an orally at a dosage of 9 mg once daily for each day of the 28-day cycle.
Letrozole
Letrozole will be given orally at a dosage of 2.5 mg once daily for each day of the 28-day cycle.
Giredestrant
Giredestrant will be given orally at a dosage of 30 mg once daily for each day of the 28-day cycle.
Abemaciclib
Giredestrant will be given orally at a dosage of 150 mg twice daily for each day of the 28-day cycle.
RECRUITING
Weill Cornell Medicine, New York
ACTIVE_NOT_RECRUITING
Roswell Park, Buffalo
ACTIVE_NOT_RECRUITING
University of Pittsburgh Medical Center, Pittsburgh
RECRUITING
Medstar Georgetown Cancer Institute, Washington D.C.
RECRUITING
Duke University Cancer Center, Durham
RECRUITING
Mount Sinai Comprehensive Cancer Center, Miami Beach
WITHDRAWN
Baptist Memorial Hospital, Memphis
RECRUITING
University of Minnesota, Minneapolis
RECRUITING
University of Chicago, Chicago
WITHDRAWN
Washington University School of Medicine Siteman Cancer Center, St Louis
RECRUITING
University of Kansas Cancer Center, Westwood
RECRUITING
Nebraska Methodist Hospital, Omaha
RECRUITING
University of Oklahoma Health Stephenson Cancer Center, Oklahoma City
ACTIVE_NOT_RECRUITING
City of Hope Comprehensive Cancer Center, Duarte
RECRUITING
UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco
RECRUITING
Providence Portland Cancer Institute, Portland
RECRUITING
Maine Medical Center, Scarborough
RECRUITING
Dana Farber Cancer Institute, Boston
ACTIVE_NOT_RECRUITING
Englewood Health, Englewood
RECRUITING
Atlantic Health Systems/Morristown Medical Center, Morristown
RECRUITING
Lifespan - Rhode Island Hospital, Providence
Collaborators (3)
Genentech, Inc.
INDUSTRY
Foundation Medicine
INDUSTRY
Pfizer
INDUSTRY
Eli Lilly and Company
INDUSTRY
Alliance Foundation Trials, LLC.
OTHER