Eosinophil-guided Reduction of Inhaled Corticosteroids

PHASE4RecruitingINTERVENTIONAL
Enrollment

444

Participants

Timeline

Start Date

June 28, 2021

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2026

Conditions
COPDInhaled CorticosteroidAzithromycinCOPD ExacerbationPneumonia
Interventions
DRUG

Azithromycin

Prophylactic azithromycin treatment 250 mg three times weekly vs placebo

DRUG

ICS

All patients will receive LABA/LAMA medication. The ICS medication will be switched on/off according to the most recent blood eosinophil count (at inclusion + every 3 months) vs continued LABA/LAMA/ICS treatment

Trial Locations (9)

Unknown

RECRUITING

Aarhus University Hospital, Aarhus

RECRUITING

Hvidovre Hospital, Copenhagen

RECRUITING

Sydvestjysk Sygehus Esbjerg, Esbjerg

RECRUITING

Gentofte Hospital, Hellerup

RECRUITING

Nordsjællands Hospital, Hillerød

RECRUITING

Næstved-Slagelse-Ringsted Sygehus, Næstved

RECRUITING

Odense University Hospital, Odense

RECRUITING

Roskilde Sygehus, Roskilde

RECRUITING

Silkeborg Sygehus, Silkeborg

All Listed Sponsors
lead

Chronic Obstructive Pulmonary Disease Trial Network, Denmark

OTHER