49
Participants
Start Date
November 11, 2020
Primary Completion Date
September 1, 2025
Study Completion Date
September 1, 2030
External beam radiotherapy
External beam radiotherapy will be delivered to a total dose of 50.4 Gy in 28 fractions of 1.8 Gy, 5 fractions per week, starting the first day of the first cycle of chemotherapy
Bintrafusp alfa
Bintrafusp alfa will be given i.v. every three weeks on day 1, 22, and 43 at a dose of 2400 mg.
Paclitaxel
Paclitaxel 50 mg/m2 will be given intravenously (i.v.) on days 1, 8, 15, 22, 29 and 36.
Carboplatin
Carboplatin AUC = 2 will be given intravenously (i.v.) on days 1, 8, 15, 22, 29 and 36.
RECRUITING
Academic Medical Center, Medical Oncology, Amsterdam
Collaborators (2)
UMC Utrecht
OTHER
Catharina Ziekenhuis Eindhoven
OTHER
Institute Verbeeten
OTHER
Elisabeth-TweeSteden Ziekenhuis
OTHER
Leiden University Medical Center
OTHER
Radiotherapeutic Institute Friesland
OTHER
Frisius Medisch Centrum
OTHER
Radiotherapy Group Deventer
OTHER
Deventer Ziekenhuis
OTHER
Rijnstate Hospital
OTHER
Erasmus Medical Center
OTHER
The Netherlands Cancer Institute
OTHER
Isala
OTHER
University Medical Center Groningen
OTHER
Ziekenhuisgroep Twente
OTHER
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
OTHER