Thoracic Radiotherapy Plus Maintenance Durvalumab After First Line Carboplatin and Etoposide Plus Durvalumab in Extensive-stage Disease Small Cell Lung Cancer (ED-SCLC).

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

46

Participants

Timeline

Start Date

June 25, 2021

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
Small Cell Lung CancerLung Cancer
Interventions
DRUG

Durvalumab

Durvalumab: 1500 mg iv

DRUG

carboplatin

Carboplatin: AUC 5 mg/mL/min iv

DRUG

etoposide

Etoposide: 100 mg/m2 iv

RADIATION

Thoracic radiotherapy

Thoracic radiotherapy: 39 Gy in 13 fractions, starting 3-8 weeks after day 1 of last cycle of induction treatment, over 2.5 weeks Prophylactic cranial irradiation (PCI) is allowed but optional: according to local practice, starting 3-8 weeks after day 1 of last cycle of induction treatment Follow up phase Patients will be followed up for 24 months, every 8 weeks.

Trial Locations (14)

1211

Hôpitaux Universitaires de Genève, Geneva

1752

HFR Freiburg - Kantonsspital, Villars-sur-Glâne

3010

Inselspital Bern, Bern

3600

Regionalspital Thun, Thun

4031

Universitaetsspital Basel, Basel

6500

IOSI Ospedale Regionale di Bellinzona e Valli, Bellinzona

8091

UniversitätsSpital Zürich, Zurich

8401

Kantonsspital Winterthur, Winterthur

8708

Klinik Hirslanden, Männedorf

Spital Männedorf, Männedorf

CH-5001

Kantonsspital Aarau, Aarau

CH-7000

Kantonsspital Graubuenden, Chur

CH-4600

Kantonsspital Olten, Olten

CH-9007

Kantonsspital - St. Gallen, Sankt Gallen

All Listed Sponsors
lead

Swiss Cancer Institute

OTHER