Efficacy and Safety of CRT, Durvalumab and Surgery for SST

Cisplatin 60 mg/m2, IV, day 1

80 - 120 mg/day, PO, day 1-14

66 Gy/33 Fr

preoperative durvalumab therapy within 28 days after chemoradiotherapy. Two courses are given every two weeks.

Surgery will be performed between day 15 and day 42 of the second course of preoperative durvalumab therapy after confirming that all surgical operation criteria are met.

"(For resectable SST) Postoperative durvalumab therapy will be started between day 28 and day 63 with the day of surgery as Day 1. Twenty-two courses are given as a 2-week course.~Drug: Durvalumab 10 mg/kg/body, IV, day 1 (For unreectable SST) Additional durvalumab therapy between day 15 and day 28 of the second course of preoperative durvalumab therapy.~Twenty-two courses are given as 2-week course. Drug: Durvalumab 10 mg/kg/body, IV, day 1"