Acalabrutinib and Durvalumab in Primary and Secondary Central Nervous System Lymphoma

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

25

Participants

Timeline

Start Date

April 29, 2021

Primary Completion Date

January 31, 2026

Study Completion Date

October 31, 2027

Conditions
Primary Central Nervous System Lymphoma
Interventions
DRUG

Durvalumab

Durvalumab will be administered over 60 minutes

DRUG

Acalabrutinib

Patients will take acalabrutinib orally every 12 hours (+/- 3 hours) daily.

Trial Locations (2)

43210

The Ohio State University Hospital, Columbus

63110

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Washington University School of Medicine

OTHER