A Study of SBT6050 Alone and in Combination With PD-1 Inhibitors in Subjects With Advanced HER2 Expressing Solid Tumors

PHASE1UnknownINTERVENTIONAL
Enrollment

58

Participants

Timeline

Start Date

July 27, 2020

Primary Completion Date

December 31, 2022

Study Completion Date

December 31, 2022

Conditions
HER2 Positive Solid Tumors
Interventions
DRUG

SBT6050

Escalating doses of SBT6050 in Part 1 and recommended dose in Part 2

DRUG

pembrolizumab

400 mg IV

DRUG

Cemiplimab

350 mg IV

Trial Locations (12)

2109

Macquarie University Hospital Clinical Trials Unit, Sydney

3000

Peter MacCallum Cancer Centre, Melbourne

6009

Breast Cancer Research Centre - WA, Nedlands

15232

University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh

27708

Duke University, Durham

37203

Sarah Cannon Research Institute/Tennessee Oncology, Nashville

77030

MD Anderson Cancer Center, Houston

78229

The START Center for Cancer Care, San Antonio

02114

Massachusetts General Hospital, Boston

03080

Seoul National University Hospital, Seoul

05505

Asan Medical Center, Seoul

06351

Samsung Medical Center, Seoul

Sponsors
All Listed Sponsors
lead

Silverback Therapeutics

INDUSTRY