Zanubrutinib, Lenalidomide and Rituximab (ZR2) in Elderly Treatment-naive Patients With Diffuse Large B-cell Lymphoma (DLBCL)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 26, 2020

Primary Completion Date

February 16, 2022

Study Completion Date

December 1, 2025

Conditions
Diffuse Large B Cell Lymphoma
Interventions
DRUG

Zanubrutinib, Lenalidomide and Rituximab (ZR2)

"Induction therapy:~The ZR2 regimen will be given from day 1 of each cycle of treatment. Each cycle will last for 21 days. Participants will receive a total of 6 cycles.~Dosage:~1. Zanubrutinib, 160 mg bid, po, day 1-21;~2. Lenalidomide, 25 mg qd, po, day 2-11;~3. Rituximab, 375 mg/m2, ivgtt, day 1.~Maintenance therapy:~Patients who receive complete response or partial response after induction therapy will receive lenalidomide 25 mg qd po during 1-10 days in every 21 days, for a maximum of 2 years."

Trial Locations (1)

200025

Shanghai Ruijin Hospital, Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER